Mesenteric Panniculitis in a Patient with Homozygous Factor V Leiden Gene Mutation: A Case and Literature to Review

• Main Authors: Muhammad Sohaib Asghar, Abubakar Tauseef, Durre Naman, Maryam Zafar, Uzma Rasheed, Narmin Khan, Haris Alvi, Nimra Shaikh
• Format: Article
• Language: English
• Published: European Medical Journal 2020-06-01
• Series: European Medical Journal
• Subjects: inflammation; mesenteric panniculitis; mesentery; factor v leiden; fibrosis; venous thrombosis
• Online Access: https://www.emjreviews.com/gastroenterology/article/mesenteric-panniculitis-in-a-patient-with-homozygous-factor-v-leiden-gene-mutation-a-case-and-literature-to-review/

A 30-year-old Asian male with a significant history of deep vein thrombosis and family history positive for pulmonary embolism presented with complaints of fever, nonradiating epigastric pain, and a sense of abdominal fullness. After the initial workup, ultrasonography of the whole abdomen was carried out which showed thrombus formation in the portal vein. A CT scan of the abdomen was performed, which showed findings suggestive of mesenteric panniculitis. Keeping the significant family history and imaging findings in mind, the clotting and thrombin profiles were analysed and came back positive for the factor V Leiden gene (homozygous). A CT angiogram was performed to demonstrate extensive thrombosis throughout the abdominal vasculature with cavernous transformation. It is asserted that the chronic thrombosis on a background of factor V mutation led towards chronic inflammation of the mesentery. To the authors’ knowledge it is the first reported case of mesenteric panniculitis in a patient with factor V homozygous gene mutation.