Proteins as the molecular markers of male fertility

• Main Authors: Eswari Beeram, Bukke Suman, Bysani Divya
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Journal of Human Reproductive Sciences
• Subjects: Amyloid precursor protein; DYNLT1; Nanos2; RBM5
• Online Access: http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=1;spage=19;epage=23;aulast=Beeram

Proteins play a key role in many functions such as metabolic activity, differentiation, as cargos, and cell fate regulators. It is necessary to know about the proteins involved in male fertility to develop remedies for the treatment of male infertility. However, the role of the proteins is not limited to particular aspect in the biological systems. Some of the proteins act as ion channels such as catsper, and protein such as Nanos is a translational repressor in germ cells and expressed in prenatal period whose role in male fertility is not clearly understood. Rbm5 is a pre-mRNA splicing factor necessary for sperm differentiation whose loss results in deficit in sperm production. DEFB114 is a beta-defensin family protein necessary for sperm motility in lipopolysaccharide-challenged mice. TEX101 is a plasma membrane specific germ cell protein whose function is not clearly identified. Gpr56 is an another adhesion protein whose null mutation leads to arrest of production of pupps. Amyloid precursor protein in Alzheimer's disease plays a role in male fertility whose function is uncertain which has to be considered while targeting them. The study on amyloid precursor protein in male fertility is a novel thing, but requires further study in correlation to Alzheimer's disease.