Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study
Background It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker of iron metabolism, and type 2 diabetes. Thus, we investigated the association between transferri...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Academya Publishing Co.
2020-09-01
|
Series: | Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://www.e-enm.org/upload/pdf/enm-2020-721.pdf |
id |
doaj-2ac4d046bcab48438870454993f50896 |
---|---|
record_format |
Article |
spelling |
doaj-2ac4d046bcab48438870454993f508962020-11-25T03:54:38ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782020-09-0135361061710.3803/EnM.2020.7212079Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal StudyJong Dai Kim0Dong-Mee Lim1Keun-Young Park2Se Eun Park3Eun Jung Rhee4Cheol-Young Park5Won-Young Lee6Ki Won Oh7 Division of Endocrinology, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea Division of Endocrinology, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea Division of Endocrinology, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker of iron metabolism, and type 2 diabetes. Thus, we investigated the association between transferrin and incident type 2 diabetes. Methods Total 31,717 participants (mean age, 40.4±7.2 years) in a health screening program in 2005 were assessed via cross-sectional analysis. We included 30,699 subjects who underwent medical check-up in 2005 and 2009 and did not have type 2 diabetes at baseline in this retrospective longitudinal analysis. Results The serum transferrin level was higher in the type 2 diabetes group than in the non-type 2 diabetes group (58.32±7.74 μmol/L vs. 56.17±7.96 μmol/L, P<0.001). Transferrin correlated with fasting serum glucose and glycosylated hemoglobin in the correlational analysis (r=0.062, P<0.001 and r=0.077, P<0.001, respectively) after full adjustment for covariates. Transferrin was more closely related to homeostasis model assessment of insulin resistance than to homeostasis model assessment of β cell function (r=0.042, P<0.001 and r=−0.019, P=0.004, respectively) after full adjustment. Transferrin predicted incident type 2 diabetes in non-type 2 diabetic subjects in a multivariate linear regression analysis; the odds ratio (95% confidence interval [CI]) of the 3rd tertile compared to that in the 1st tertile of transferrin for incident diabetes was 1.319 (95% CI, 1.082 to 1.607) after full adjustment (P=0.006). Conclusion Transferrin is positively associated with incident type 2 diabetes in Koreans.http://www.e-enm.org/upload/pdf/enm-2020-721.pdftransferrindiabetes mellitus, type 2insulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jong Dai Kim Dong-Mee Lim Keun-Young Park Se Eun Park Eun Jung Rhee Cheol-Young Park Won-Young Lee Ki Won Oh |
spellingShingle |
Jong Dai Kim Dong-Mee Lim Keun-Young Park Se Eun Park Eun Jung Rhee Cheol-Young Park Won-Young Lee Ki Won Oh Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study Endocrinology and Metabolism transferrin diabetes mellitus, type 2 insulin resistance |
author_facet |
Jong Dai Kim Dong-Mee Lim Keun-Young Park Se Eun Park Eun Jung Rhee Cheol-Young Park Won-Young Lee Ki Won Oh |
author_sort |
Jong Dai Kim |
title |
Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study |
title_short |
Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study |
title_full |
Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study |
title_fullStr |
Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study |
title_full_unstemmed |
Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study |
title_sort |
serum transferrin predicts new-onset type 2 diabetes in koreans: a 4-year retrospective longitudinal study |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2020-09-01 |
description |
Background It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker of iron metabolism, and type 2 diabetes. Thus, we investigated the association between transferrin and incident type 2 diabetes. Methods Total 31,717 participants (mean age, 40.4±7.2 years) in a health screening program in 2005 were assessed via cross-sectional analysis. We included 30,699 subjects who underwent medical check-up in 2005 and 2009 and did not have type 2 diabetes at baseline in this retrospective longitudinal analysis. Results The serum transferrin level was higher in the type 2 diabetes group than in the non-type 2 diabetes group (58.32±7.74 μmol/L vs. 56.17±7.96 μmol/L, P<0.001). Transferrin correlated with fasting serum glucose and glycosylated hemoglobin in the correlational analysis (r=0.062, P<0.001 and r=0.077, P<0.001, respectively) after full adjustment for covariates. Transferrin was more closely related to homeostasis model assessment of insulin resistance than to homeostasis model assessment of β cell function (r=0.042, P<0.001 and r=−0.019, P=0.004, respectively) after full adjustment. Transferrin predicted incident type 2 diabetes in non-type 2 diabetic subjects in a multivariate linear regression analysis; the odds ratio (95% confidence interval [CI]) of the 3rd tertile compared to that in the 1st tertile of transferrin for incident diabetes was 1.319 (95% CI, 1.082 to 1.607) after full adjustment (P=0.006). Conclusion Transferrin is positively associated with incident type 2 diabetes in Koreans. |
topic |
transferrin diabetes mellitus, type 2 insulin resistance |
url |
http://www.e-enm.org/upload/pdf/enm-2020-721.pdf |
work_keys_str_mv |
AT jongdaikim serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT dongmeelim serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT keunyoungpark serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT seeunpark serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT eunjungrhee serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT cheolyoungpark serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT wonyounglee serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy AT kiwonoh serumtransferrinpredictsnewonsettype2diabetesinkoreansa4yearretrospectivelongitudinalstudy |
_version_ |
1724472564435124224 |