Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model
Some previous studies reported a benefit to cardiopulmonary transition at birth when starting resuscitation maneuvers while the cord was still intact for a short period of time. However, the best timing for umbilical cord clamping in this condition is unknown. The aim of this study was to explore th...
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doaj-2acad5fc3f554cd4916744ceea0d79ae2021-04-26T23:01:42ZengMDPI AGChildren2227-90672021-04-01833733710.3390/children8050337Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb ModelKévin Le Duc0Estelle Aubry1Sébastien Mur2Capucine Besengez3Charles Garabedian4Julien De Jonckheere5Laurent Storme6Dyuti Sharma7Univ. Lille, ULR2694 Metrics—Perinatal Environment and Health, F-59000 Lille, FranceCHU Lille, Department of Pediatric Surgery, Jeanne de Flandre Hospital, F-59000 Lille, FranceCHU Lille, Department of Neonatology, Jeanne de Flandre Hospital, F-59000 Lille, FranceUniv. Lille, ULR2694 Metrics—Perinatal Environment and Health, F-59000 Lille, FranceUniv. Lille, ULR2694 Metrics—Perinatal Environment and Health, F-59000 Lille, FranceUniv. Lille, ULR2694 Metrics—Perinatal Environment and Health, F-59000 Lille, FranceUniv. Lille, ULR2694 Metrics—Perinatal Environment and Health, F-59000 Lille, FranceUniv. Lille, ULR2694 Metrics—Perinatal Environment and Health, F-59000 Lille, FranceSome previous studies reported a benefit to cardiopulmonary transition at birth when starting resuscitation maneuvers while the cord was still intact for a short period of time. However, the best timing for umbilical cord clamping in this condition is unknown. The aim of this study was to explore the duration of effective umbilico–placental circulation able to promote cardiorespiratory adaptation at birth during intact cord resuscitation. Umbilico–placental blood flow and vascular resistances were measured in an experimental neonatal lamb model. After a C-section delivery, the lambs were resuscitated ventilated for 1 h while the cord was intact. The maximum and mean umbilico–placental blood flow were respectively 230 ± 75 and 160 ± 12 mL·min<sup>−1</sup> during the 1 h course of the experiment. However, umbilico–placental blood flow decreased and vascular resistance increased significantly 40 min after birth (<i>p</i> < 0.05). These results suggest that significant cardiorespiratory support can be provided by sustained placental circulation for at least 1 h during intact cord resuscitation.https://www.mdpi.com/2227-9067/8/5/337delayed cord clampingintact cord resuscitationumbilico–placental circulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kévin Le Duc Estelle Aubry Sébastien Mur Capucine Besengez Charles Garabedian Julien De Jonckheere Laurent Storme Dyuti Sharma |
spellingShingle |
Kévin Le Duc Estelle Aubry Sébastien Mur Capucine Besengez Charles Garabedian Julien De Jonckheere Laurent Storme Dyuti Sharma Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model Children delayed cord clamping intact cord resuscitation umbilico–placental circulation |
author_facet |
Kévin Le Duc Estelle Aubry Sébastien Mur Capucine Besengez Charles Garabedian Julien De Jonckheere Laurent Storme Dyuti Sharma |
author_sort |
Kévin Le Duc |
title |
Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model |
title_short |
Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model |
title_full |
Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model |
title_fullStr |
Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model |
title_full_unstemmed |
Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model |
title_sort |
changes in umbilico–placental circulation during prolonged intact cord resuscitation in a lamb model |
publisher |
MDPI AG |
series |
Children |
issn |
2227-9067 |
publishDate |
2021-04-01 |
description |
Some previous studies reported a benefit to cardiopulmonary transition at birth when starting resuscitation maneuvers while the cord was still intact for a short period of time. However, the best timing for umbilical cord clamping in this condition is unknown. The aim of this study was to explore the duration of effective umbilico–placental circulation able to promote cardiorespiratory adaptation at birth during intact cord resuscitation. Umbilico–placental blood flow and vascular resistances were measured in an experimental neonatal lamb model. After a C-section delivery, the lambs were resuscitated ventilated for 1 h while the cord was intact. The maximum and mean umbilico–placental blood flow were respectively 230 ± 75 and 160 ± 12 mL·min<sup>−1</sup> during the 1 h course of the experiment. However, umbilico–placental blood flow decreased and vascular resistance increased significantly 40 min after birth (<i>p</i> < 0.05). These results suggest that significant cardiorespiratory support can be provided by sustained placental circulation for at least 1 h during intact cord resuscitation. |
topic |
delayed cord clamping intact cord resuscitation umbilico–placental circulation |
url |
https://www.mdpi.com/2227-9067/8/5/337 |
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