Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature

Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature

In our hands, efficient access to the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one kinase hinge-binder motif proved to be more challenging than anticipated requiring a significant investment in route scouting and optimization. This full paper focuses on the synthesis issues that we encount...

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Bibliographic Details
Main Authors: Romain Pierre, Anne Brethon, Sylvain A. Jacques, Aurélie Blond, Sandrine Chambon, Sandrine Talano, Catherine Raffin, Branislav Musicki, Claire Bouix-Peter, Loic Tomas, Gilles Ouvry, Rémy Morgentin, Laurent F. Hennequin, Craig S. Harris
Format: Article
Language:English
Published: Beilstein-Institut 2021-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
7-azabenzotriazole
hinge-binder
ionic hydrogenation
library
pyridine-2(1h)-one
Online Access:https://doi.org/10.3762/bjoc.17.16

Internet

https://doi.org/10.3762/bjoc.17.16

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