Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>

Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>

Seven new sesquiterpenoids, lochmolins A–G (<strong>1</strong>–<strong>7</strong>), were isolated from a Taiwanese soft coral <em>Sinularia lochmodes</em>. The structures of these metabolites were elucidated by exten...

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Main Authors: Jyh-Horng Sheu, Chiung-Yao Huang, Hui-Li Lin, Kuo-Ping Shen, Yen-Ju Tseng, Chang-Feng Dai
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Marine Drugs
Subjects:
soft coral
<em>Sinularia</em><em> </em><em>lochmodes</em>
sesquiterpenes
aromadendrane
germacrane
Online Access:http://www.mdpi.com/1660-3397/10/7/1572
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spelling doaj-2ad047b0d11e4f6da7ec5bd41976af622020-11-24T23:00:38ZengMDPI AGMarine Drugs1660-33972012-07-011071572158110.3390/md10071572Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>Jyh-Horng SheuChiung-Yao HuangHui-Li LinKuo-Ping ShenYen-Ju TsengChang-Feng DaiSeven new sesquiterpenoids, lochmolins A–G (<strong>1</strong>–<strong>7</strong>), were isolated from a Taiwanese soft coral <em>Sinularia lochmodes</em>. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds <strong>1</strong>–<strong>4</strong> were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.http://www.mdpi.com/1660-3397/10/7/1572soft coral<em>Sinularia</em><em> </em><em>lochmodes</em>sesquiterpenesaromadendranegermacrane
collection DOAJ
language English
format Article
sources DOAJ
author Jyh-Horng Sheu
Chiung-Yao Huang
Hui-Li Lin
Kuo-Ping Shen
Yen-Ju Tseng
Chang-Feng Dai
spellingShingle Jyh-Horng Sheu
Chiung-Yao Huang
Hui-Li Lin
Kuo-Ping Shen
Yen-Ju Tseng
Chang-Feng Dai
Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>
Marine Drugs
soft coral
<em>Sinularia</em><em> </em><em>lochmodes</em>
sesquiterpenes
aromadendrane
germacrane
author_facet Jyh-Horng Sheu
Chiung-Yao Huang
Hui-Li Lin
Kuo-Ping Shen
Yen-Ju Tseng
Chang-Feng Dai
author_sort Jyh-Horng Sheu
title Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>
title_short Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>
title_full Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>
title_fullStr Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>
title_full_unstemmed Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>
title_sort lochmolins a–g, new sesquiterpenoids from the soft coral <em>sinularia</em><em> lochmodes</em>
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2012-07-01
description Seven new sesquiterpenoids, lochmolins A–G (<strong>1</strong>–<strong>7</strong>), were isolated from a Taiwanese soft coral <em>Sinularia lochmodes</em>. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds <strong>1</strong>–<strong>4</strong> were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.
topic soft coral
<em>Sinularia</em><em> </em><em>lochmodes</em>
sesquiterpenes
aromadendrane
germacrane
url http://www.mdpi.com/1660-3397/10/7/1572
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