Triple, simultaneous, very late coronary stent thrombosis

Coronary artery stent thrombosis is an uncommon but potentially catastrophic complication. The risk of very late stent thrombosis (VLST) raises important safety issues regarding the first generation of drug-eluting stents (DES). Although several complex mechanisms for VLST have been suggested and va...

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Main Authors: Miguel Silva Vieira, André Luz, Diana Anjo, Nuno Antunes, Mário Santos, Henrique Carvalho, Severo Torres
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Revista Portuguesa de Cardiologia (English Edition)
Online Access:http://www.sciencedirect.com/science/article/pii/S2174204913000743
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spelling doaj-2ade4580b4064e5fa495b612215e36b82020-11-25T00:34:40ZengElsevierRevista Portuguesa de Cardiologia (English Edition)2174-20492013-03-01323247252Triple, simultaneous, very late coronary stent thrombosisMiguel Silva Vieira0André Luz1Diana Anjo2Nuno Antunes3Mário Santos4Henrique Carvalho5Severo Torres6Corresponding author.; Cardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCardiology Department, Santo António Hospital– Centro Hospitalar do Porto, Porto, PortugalCoronary artery stent thrombosis is an uncommon but potentially catastrophic complication. The risk of very late stent thrombosis (VLST) raises important safety issues regarding the first generation of drug-eluting stents (DES). Although several complex mechanisms for VLST have been suggested and various predictors have been described, its pathophysiology is not completely understood and it is not known whether longer-term dual antiplatelet therapy reduces the risk. We present a rare case of simultaneous very late DES thrombosis in the three vascular territories, following discontinuation of antiplatelet therapy seven years after stent placement, presenting as cardiogenic shock. Resumo: A trombose de stent coronário é uma complicação rara mas potencialmente catastrófica. O risco de trombose muito tardia de stent (TMTS) tem levantado questões importantes sobre a segurança do uso de stents revestidos com fármacos (SRF) de primeira geração. Embora sejam vários e complexos os mecanismos da TMTS e vários os preditores que têm sido descritos, a sua fisiopatologia ainda não está totalmente esclarecida e desconhece-se se o prolongar da terapêutica antiagregante dupla reduz esse risco. Descrevemos um caso raro de trombose muito tardia de SRF ocorrendo em simultâneo nos três territórios vasculares, após interrupção da terapêutica antiagregante, sete anos após implantação dos stents, apresentando-se como choque cardiogénico. Keywords: Very late stent thrombosis, Drug-eluting stents, Palavras-chave: Trombose muito tardia de stent, Stents revestidoshttp://www.sciencedirect.com/science/article/pii/S2174204913000743
collection DOAJ
language English
format Article
sources DOAJ
author Miguel Silva Vieira
André Luz
Diana Anjo
Nuno Antunes
Mário Santos
Henrique Carvalho
Severo Torres
spellingShingle Miguel Silva Vieira
André Luz
Diana Anjo
Nuno Antunes
Mário Santos
Henrique Carvalho
Severo Torres
Triple, simultaneous, very late coronary stent thrombosis
Revista Portuguesa de Cardiologia (English Edition)
author_facet Miguel Silva Vieira
André Luz
Diana Anjo
Nuno Antunes
Mário Santos
Henrique Carvalho
Severo Torres
author_sort Miguel Silva Vieira
title Triple, simultaneous, very late coronary stent thrombosis
title_short Triple, simultaneous, very late coronary stent thrombosis
title_full Triple, simultaneous, very late coronary stent thrombosis
title_fullStr Triple, simultaneous, very late coronary stent thrombosis
title_full_unstemmed Triple, simultaneous, very late coronary stent thrombosis
title_sort triple, simultaneous, very late coronary stent thrombosis
publisher Elsevier
series Revista Portuguesa de Cardiologia (English Edition)
issn 2174-2049
publishDate 2013-03-01
description Coronary artery stent thrombosis is an uncommon but potentially catastrophic complication. The risk of very late stent thrombosis (VLST) raises important safety issues regarding the first generation of drug-eluting stents (DES). Although several complex mechanisms for VLST have been suggested and various predictors have been described, its pathophysiology is not completely understood and it is not known whether longer-term dual antiplatelet therapy reduces the risk. We present a rare case of simultaneous very late DES thrombosis in the three vascular territories, following discontinuation of antiplatelet therapy seven years after stent placement, presenting as cardiogenic shock. Resumo: A trombose de stent coronário é uma complicação rara mas potencialmente catastrófica. O risco de trombose muito tardia de stent (TMTS) tem levantado questões importantes sobre a segurança do uso de stents revestidos com fármacos (SRF) de primeira geração. Embora sejam vários e complexos os mecanismos da TMTS e vários os preditores que têm sido descritos, a sua fisiopatologia ainda não está totalmente esclarecida e desconhece-se se o prolongar da terapêutica antiagregante dupla reduz esse risco. Descrevemos um caso raro de trombose muito tardia de SRF ocorrendo em simultâneo nos três territórios vasculares, após interrupção da terapêutica antiagregante, sete anos após implantação dos stents, apresentando-se como choque cardiogénico. Keywords: Very late stent thrombosis, Drug-eluting stents, Palavras-chave: Trombose muito tardia de stent, Stents revestidos
url http://www.sciencedirect.com/science/article/pii/S2174204913000743
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