Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy. Age-related decline in fertility is strongly attributed to ovarian aging, diminished ovarian reserves, and decreased developmental competence of...

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Bibliographic Details
Main Authors: Hiroyuki Sasaki, Toshio Hamatani, Shintaro Kamijo, Maki Iwai, Masato Kobanawa, Seiji Ogawa, Kenji Miyado, Mamoru Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Endocrinology
Subjects:
oxidative stree
mitochondrial dysfunction
antioxidants
oocyte aging
ER stress
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00811/full

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