Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations
Abstract Background Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association...
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doaj-2aec0abfde5341549c6ba0cd323165772020-11-24T21:38:49ZengBMCLipids in Health and Disease1476-511X2018-05-0117111310.1186/s12944-018-0759-8Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populationsLing Qiu0Rui-Xing Yin1Eksavang Khounphinith2Fen-Han Zhang3De-Zhai Yang4Shang-Ling Pan5Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical UniversityDepartment of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical UniversityDepartment of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical UniversityDepartment of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical UniversityDepartment of Molecular Genetics, Medical Scientific Research Center, Guangxi Medical UniversityDepartment of Pathophysiology, School of Premedical Sciences, Guangxi Medical UniversityAbstract Background Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations. Methods Genotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing. Results The frequencies of CC, CG and GG genotypes of the APOA1 rs964184 SNP were 68.86, 29.18 and 1.96% in the Maonan population, and 63.78, 30.85 and 5.37% in the Han population (P < 0.001). The frequency of the G allele was 16.55% in Maonan and 20.79% in Han (P < 0.001). The G allele carriers had lower high-density lipoprotein cholesterol (HDL-C) levels in Maonan and higher triglyceride (TG) levels in Han peoples than the G allele non-carriers. Subgroup analyses showed that the G allele carriers had lower HDL-C levels in both Maonan males and females; and lower apolipoprotein (Apo) A1 levels and the ApoA1/ApoB ratio in Han males than the G allele non-carriers. Serum lipid parameters in the two ethnic groups were also associated with several environmental factors. Conclusions The present study reveals that there may be a racial/ethnic- and/or gender-specific association between the APOA1 rs964184 SNP and serum lipid parameters in our study populations. Trial registration Retrospectively registered.http://link.springer.com/article/10.1186/s12944-018-0759-8LipidsApolipoprotein A1Single nucleotide polymorphismEnvironmental factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ling Qiu Rui-Xing Yin Eksavang Khounphinith Fen-Han Zhang De-Zhai Yang Shang-Ling Pan |
spellingShingle |
Ling Qiu Rui-Xing Yin Eksavang Khounphinith Fen-Han Zhang De-Zhai Yang Shang-Ling Pan Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations Lipids in Health and Disease Lipids Apolipoprotein A1 Single nucleotide polymorphism Environmental factors |
author_facet |
Ling Qiu Rui-Xing Yin Eksavang Khounphinith Fen-Han Zhang De-Zhai Yang Shang-Ling Pan |
author_sort |
Ling Qiu |
title |
Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations |
title_short |
Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations |
title_full |
Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations |
title_fullStr |
Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations |
title_full_unstemmed |
Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations |
title_sort |
association of the apoa1 rs964184 snp and serum lipid traits in the chinese maonan and han populations |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2018-05-01 |
description |
Abstract Background Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations. Methods Genotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing. Results The frequencies of CC, CG and GG genotypes of the APOA1 rs964184 SNP were 68.86, 29.18 and 1.96% in the Maonan population, and 63.78, 30.85 and 5.37% in the Han population (P < 0.001). The frequency of the G allele was 16.55% in Maonan and 20.79% in Han (P < 0.001). The G allele carriers had lower high-density lipoprotein cholesterol (HDL-C) levels in Maonan and higher triglyceride (TG) levels in Han peoples than the G allele non-carriers. Subgroup analyses showed that the G allele carriers had lower HDL-C levels in both Maonan males and females; and lower apolipoprotein (Apo) A1 levels and the ApoA1/ApoB ratio in Han males than the G allele non-carriers. Serum lipid parameters in the two ethnic groups were also associated with several environmental factors. Conclusions The present study reveals that there may be a racial/ethnic- and/or gender-specific association between the APOA1 rs964184 SNP and serum lipid parameters in our study populations. Trial registration Retrospectively registered. |
topic |
Lipids Apolipoprotein A1 Single nucleotide polymorphism Environmental factors |
url |
http://link.springer.com/article/10.1186/s12944-018-0759-8 |
work_keys_str_mv |
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