Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis
Colorectal cancer: Beneficial bacteria prompt anti-tumor gene response Boosting specific beneficial bacteria in the gut may enhance expression levels of a tumor-suppressing gene in colorectal cancer (CRC). Both genetic factors and the bacteria present in the gut play vital roles in CRC development....
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-04-01
|
Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-017-0002-0 |
id |
doaj-2b060756e9164ab19a432472a382975a |
---|---|
record_format |
Article |
spelling |
doaj-2b060756e9164ab19a432472a382975a2020-12-08T13:50:57ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-04-0150411110.1038/s12276-017-0002-0Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesisYong Zhang0Xiao-lan Wang1Min Zhou2Chao Kang3He-dong Lang4Meng-ting Chen5Suo-cheng Hui6Bin Wang7Man-tian Mi8Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterResearch Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food safety; Chongqing Medical Nutrition Research CenterColorectal cancer: Beneficial bacteria prompt anti-tumor gene response Boosting specific beneficial bacteria in the gut may enhance expression levels of a tumor-suppressing gene in colorectal cancer (CRC). Both genetic factors and the bacteria present in the gut play vital roles in CRC development. However, it is unclear exactly how genes interact with the bacteria to affect tumor growth. Man-tian Mi and co-workers at the Third Military Medical University in Chongqing, China, examined the role of a gene called Sirt-3 in CRC development. Mice lacking the Sirt-3 gene suffered severe chronic inflammation and developed tumors due to altered signalling pathways and reduced intestinal integrity. Further, the guts of the mice harboured more pathogenic bacteria than wild-type mice. The team also found lower levels of two key types of beneficial bacteria that would ordinarily prevent reduced Sirt-3 expression.https://doi.org/10.1038/s12276-017-0002-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Zhang Xiao-lan Wang Min Zhou Chao Kang He-dong Lang Meng-ting Chen Suo-cheng Hui Bin Wang Man-tian Mi |
spellingShingle |
Yong Zhang Xiao-lan Wang Min Zhou Chao Kang He-dong Lang Meng-ting Chen Suo-cheng Hui Bin Wang Man-tian Mi Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis Experimental and Molecular Medicine |
author_facet |
Yong Zhang Xiao-lan Wang Min Zhou Chao Kang He-dong Lang Meng-ting Chen Suo-cheng Hui Bin Wang Man-tian Mi |
author_sort |
Yong Zhang |
title |
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis |
title_short |
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis |
title_full |
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis |
title_fullStr |
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis |
title_full_unstemmed |
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis |
title_sort |
crosstalk between gut microbiota and sirtuin-3 in colonic inflammation and tumorigenesis |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
2092-6413 |
publishDate |
2018-04-01 |
description |
Colorectal cancer: Beneficial bacteria prompt anti-tumor gene response Boosting specific beneficial bacteria in the gut may enhance expression levels of a tumor-suppressing gene in colorectal cancer (CRC). Both genetic factors and the bacteria present in the gut play vital roles in CRC development. However, it is unclear exactly how genes interact with the bacteria to affect tumor growth. Man-tian Mi and co-workers at the Third Military Medical University in Chongqing, China, examined the role of a gene called Sirt-3 in CRC development. Mice lacking the Sirt-3 gene suffered severe chronic inflammation and developed tumors due to altered signalling pathways and reduced intestinal integrity. Further, the guts of the mice harboured more pathogenic bacteria than wild-type mice. The team also found lower levels of two key types of beneficial bacteria that would ordinarily prevent reduced Sirt-3 expression. |
url |
https://doi.org/10.1038/s12276-017-0002-0 |
work_keys_str_mv |
AT yongzhang crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT xiaolanwang crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT minzhou crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT chaokang crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT hedonglang crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT mengtingchen crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT suochenghui crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT binwang crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis AT mantianmi crosstalkbetweengutmicrobiotaandsirtuin3incolonicinflammationandtumorigenesis |
_version_ |
1724389180167946240 |