Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients
<b>Background.</b> Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. <b>M...
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doaj-2b0b1486c0c346b8bfadbd409006c0ba2020-11-25T03:33:02ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0192892289210.3390/jcm9092892Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism PatientsJeremy Lagrange0Bianca Wagner1Markus Nagler2Vincent ten Cate3Alejandro Pallares Robles4Thomas Koeck5Steffen Rapp6Jürgen H. Prochaska7Henri M. Spronk8Philip Wenzel9Wolfram Ruf10Hugo ten Cate11Philipp S. Wild12Marina Panova-Noeva13Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyLaboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, 6200 MD Maastricht, The NetherlandsCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyLaboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, 6200 MD Maastricht, The NetherlandsCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany<b>Background.</b> Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. <b>Methods.</b> We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. <b>Results.</b> Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. <b>Conclusions.</b> This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation.https://www.mdpi.com/2077-0383/9/9/2892thrombin generationvenous thromboembolismplateletsfactor Xa inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeremy Lagrange Bianca Wagner Markus Nagler Vincent ten Cate Alejandro Pallares Robles Thomas Koeck Steffen Rapp Jürgen H. Prochaska Henri M. Spronk Philip Wenzel Wolfram Ruf Hugo ten Cate Philipp S. Wild Marina Panova-Noeva |
spellingShingle |
Jeremy Lagrange Bianca Wagner Markus Nagler Vincent ten Cate Alejandro Pallares Robles Thomas Koeck Steffen Rapp Jürgen H. Prochaska Henri M. Spronk Philip Wenzel Wolfram Ruf Hugo ten Cate Philipp S. Wild Marina Panova-Noeva Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients Journal of Clinical Medicine thrombin generation venous thromboembolism platelets factor Xa inhibitor |
author_facet |
Jeremy Lagrange Bianca Wagner Markus Nagler Vincent ten Cate Alejandro Pallares Robles Thomas Koeck Steffen Rapp Jürgen H. Prochaska Henri M. Spronk Philip Wenzel Wolfram Ruf Hugo ten Cate Philipp S. Wild Marina Panova-Noeva |
author_sort |
Jeremy Lagrange |
title |
Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients |
title_short |
Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients |
title_full |
Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients |
title_fullStr |
Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients |
title_full_unstemmed |
Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients |
title_sort |
characterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patients |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-09-01 |
description |
<b>Background.</b> Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. <b>Methods.</b> We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. <b>Results.</b> Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. <b>Conclusions.</b> This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation. |
topic |
thrombin generation venous thromboembolism platelets factor Xa inhibitor |
url |
https://www.mdpi.com/2077-0383/9/9/2892 |
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