The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering
Bone tissue engineering commonly encompasses the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the propagation of cells to regenerate damaged tissues or organs. 3D printing technology has been extensively applied to allow direct 3D scaffolds manufacturing. Polyca...
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doaj-2b154f3771f04bcfbf00ebe217873a112021-08-26T14:15:27ZengMDPI AGPolymers2073-43602021-08-01132754275410.3390/polym13162754The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue EngineeringXiangjun Yang0Yuting Wang1Ying Zhou2Junyu Chen3Qianbing Wan4Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaBone tissue engineering commonly encompasses the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the propagation of cells to regenerate damaged tissues or organs. 3D printing technology has been extensively applied to allow direct 3D scaffolds manufacturing. Polycaprolactone (PCL) has been widely used in the fabrication of 3D scaffolds in the field of bone tissue engineering due to its advantages such as good biocompatibility, slow degradation rate, the less acidic breakdown products in comparison to other polyesters, and the potential for loadbearing applications. PCL can be blended with a variety of polymers and hydrogels to improve its properties or to introduce new PCL-based composites. This paper describes the PCL used in developing state of the art of scaffolds for bone tissue engineering. In this review, we provide an overview of the 3D printing techniques for the fabrication of PCL-based composite scaffolds and recent studies on applications in different clinical situations. For instance, PCL-based composite scaffolds were used as an implant surgical guide in dental treatment. Furthermore, future trend and potential clinical translations will be discussed.https://www.mdpi.com/2073-4360/13/16/2754polycaprolactonethree-dimensional scaffoldsbone tissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiangjun Yang Yuting Wang Ying Zhou Junyu Chen Qianbing Wan |
spellingShingle |
Xiangjun Yang Yuting Wang Ying Zhou Junyu Chen Qianbing Wan The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering Polymers polycaprolactone three-dimensional scaffolds bone tissue engineering |
author_facet |
Xiangjun Yang Yuting Wang Ying Zhou Junyu Chen Qianbing Wan |
author_sort |
Xiangjun Yang |
title |
The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering |
title_short |
The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering |
title_full |
The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering |
title_fullStr |
The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering |
title_full_unstemmed |
The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering |
title_sort |
application of polycaprolactone in three-dimensional printing scaffolds for bone tissue engineering |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2021-08-01 |
description |
Bone tissue engineering commonly encompasses the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the propagation of cells to regenerate damaged tissues or organs. 3D printing technology has been extensively applied to allow direct 3D scaffolds manufacturing. Polycaprolactone (PCL) has been widely used in the fabrication of 3D scaffolds in the field of bone tissue engineering due to its advantages such as good biocompatibility, slow degradation rate, the less acidic breakdown products in comparison to other polyesters, and the potential for loadbearing applications. PCL can be blended with a variety of polymers and hydrogels to improve its properties or to introduce new PCL-based composites. This paper describes the PCL used in developing state of the art of scaffolds for bone tissue engineering. In this review, we provide an overview of the 3D printing techniques for the fabrication of PCL-based composite scaffolds and recent studies on applications in different clinical situations. For instance, PCL-based composite scaffolds were used as an implant surgical guide in dental treatment. Furthermore, future trend and potential clinical translations will be discussed. |
topic |
polycaprolactone three-dimensional scaffolds bone tissue engineering |
url |
https://www.mdpi.com/2073-4360/13/16/2754 |
work_keys_str_mv |
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