Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea.

Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea.

Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor negatively regulating mammalian target of rapamycin complex 1 (mTORC1). It is reported that mice lacking Tsc1 gene in oocytes show depletion of primordial follicles, resulting in premature ovarian failure and subsequent infertility. A recent...

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Bibliographic Details
Main Authors: Lin Huang, Zhen-Bo Wang, Zong-Zhe Jiang, Meng-Wen Hu, Fei Lin, Qing-Hua Zhang, Yi-Bo Luo, Yi Hou, Yong Zhao, Heng-Yu Fan, Heide Schatten, Qing-Yuan Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3545997?pdf=render

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http://europepmc.org/articles/PMC3545997?pdf=render

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