Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance
Natural antibodies to the tumor-associated Thomsen-Friedenreich antigen (TF) are related to tumor immunosurveillance and cancer patients’ survival. Hidden IgG antibodies (HAbs) to TF, their lectin reactivity, avidity, and clinical relevance were studied. HAbs were present in cancer patients and cont...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2017/6097647 |
id |
doaj-2b17288f77694a32abdccbcb1432a8f7 |
---|---|
record_format |
Article |
spelling |
doaj-2b17288f77694a32abdccbcb1432a8f72020-11-24T20:51:02ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/60976476097647Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical RelevanceOleg Kurtenkov0Kersti Klaamas1Department of Oncology and Immunology, National Institute for Health Development, Hiiu 42, 11619 Tallinn, EstoniaDepartment of Oncology and Immunology, National Institute for Health Development, Hiiu 42, 11619 Tallinn, EstoniaNatural antibodies to the tumor-associated Thomsen-Friedenreich antigen (TF) are related to tumor immunosurveillance and cancer patients’ survival. Hidden IgG antibodies (HAbs) to TF, their lectin reactivity, avidity, and clinical relevance were studied. HAbs were present in cancer patients and controls. A decreased level of IgG HAbs was detected in cancer. The HAbs level positively correlated with the sialospecific SNA lectin binding in purified total IgG (tIgG) in donors and cancer patients, indicating that HAbs are higher sialylated. The avidity of anti-TF IgG in tIgG samples was lower in cancer patients (P=0.025) while no difference in the avidity of free anti-TF IgG was established. A negative correlation between the avidity of anti-TF IgG in tIgG and SNA binding in both groups was observed (P<0.0001). The HAbs level negatively correlated with the anti-TF IgG avidity in tIgG only in donors (P=0.003). Changes in the level of HAbs and Abs avidity showed a rather good stage- and gender-dependent diagnostic accuracy. Cancer patients with a lower anti-TF IgG avidity in tIgG showed a benefit in survival. Thus the TF-specific HAbs represent a particular subset of anti-TF IgG that differ from free serum anti-TF IgG in SNA reactivity, avidity, diagnostic potential, and relation to survival.http://dx.doi.org/10.1155/2017/6097647 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oleg Kurtenkov Kersti Klaamas |
spellingShingle |
Oleg Kurtenkov Kersti Klaamas Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance BioMed Research International |
author_facet |
Oleg Kurtenkov Kersti Klaamas |
author_sort |
Oleg Kurtenkov |
title |
Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance |
title_short |
Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance |
title_full |
Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance |
title_fullStr |
Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance |
title_full_unstemmed |
Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance |
title_sort |
hidden igg antibodies to the tumor-associated thomsen-friedenreich antigen in gastric cancer patients: lectin reactivity, avidity, and clinical relevance |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
Natural antibodies to the tumor-associated Thomsen-Friedenreich antigen (TF) are related to tumor immunosurveillance and cancer patients’ survival. Hidden IgG antibodies (HAbs) to TF, their lectin reactivity, avidity, and clinical relevance were studied. HAbs were present in cancer patients and controls. A decreased level of IgG HAbs was detected in cancer. The HAbs level positively correlated with the sialospecific SNA lectin binding in purified total IgG (tIgG) in donors and cancer patients, indicating that HAbs are higher sialylated. The avidity of anti-TF IgG in tIgG samples was lower in cancer patients (P=0.025) while no difference in the avidity of free anti-TF IgG was established. A negative correlation between the avidity of anti-TF IgG in tIgG and SNA binding in both groups was observed (P<0.0001). The HAbs level negatively correlated with the anti-TF IgG avidity in tIgG only in donors (P=0.003). Changes in the level of HAbs and Abs avidity showed a rather good stage- and gender-dependent diagnostic accuracy. Cancer patients with a lower anti-TF IgG avidity in tIgG showed a benefit in survival. Thus the TF-specific HAbs represent a particular subset of anti-TF IgG that differ from free serum anti-TF IgG in SNA reactivity, avidity, diagnostic potential, and relation to survival. |
url |
http://dx.doi.org/10.1155/2017/6097647 |
work_keys_str_mv |
AT olegkurtenkov hiddeniggantibodiestothetumorassociatedthomsenfriedenreichantigeningastriccancerpatientslectinreactivityavidityandclinicalrelevance AT kerstiklaamas hiddeniggantibodiestothetumorassociatedthomsenfriedenreichantigeningastriccancerpatientslectinreactivityavidityandclinicalrelevance |
_version_ |
1716802997533540352 |