Complex DNA knots detected with a nanopore sensor
Nanopore microscopy is capable of detecting knots in DNA polymers, a common structural feature. Here the authors show nanopore sensors can map the equilibrium structure of these knots between tight and loose states.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12358-4 |
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Article |
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doaj-2b1a76737001404d80ef253081485b512021-05-11T11:46:59ZengNature Publishing GroupNature Communications2041-17232019-10-011011910.1038/s41467-019-12358-4Complex DNA knots detected with a nanopore sensorRajesh Kumar Sharma0Ishita Agrawal1Liang Dai2Patrick S. Doyle3Slaven Garaj4Department of Biomedical Engineering, National University of SingaporeDepartment of Biomedical Engineering, National University of SingaporeDepartment of Physics, City University of Hong KongSingapore-MIT Alliance for Research and Technology CentreDepartment of Biomedical Engineering, National University of SingaporeNanopore microscopy is capable of detecting knots in DNA polymers, a common structural feature. Here the authors show nanopore sensors can map the equilibrium structure of these knots between tight and loose states.https://doi.org/10.1038/s41467-019-12358-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Rajesh Kumar Sharma Ishita Agrawal Liang Dai Patrick S. Doyle Slaven Garaj |
| spellingShingle |
Rajesh Kumar Sharma Ishita Agrawal Liang Dai Patrick S. Doyle Slaven Garaj Complex DNA knots detected with a nanopore sensor Nature Communications |
| author_facet |
Rajesh Kumar Sharma Ishita Agrawal Liang Dai Patrick S. Doyle Slaven Garaj |
| author_sort |
Rajesh Kumar Sharma |
| title |
Complex DNA knots detected with a nanopore sensor |
| title_short |
Complex DNA knots detected with a nanopore sensor |
| title_full |
Complex DNA knots detected with a nanopore sensor |
| title_fullStr |
Complex DNA knots detected with a nanopore sensor |
| title_full_unstemmed |
Complex DNA knots detected with a nanopore sensor |
| title_sort |
complex dna knots detected with a nanopore sensor |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-10-01 |
| description |
Nanopore microscopy is capable of detecting knots in DNA polymers, a common structural feature. Here the authors show nanopore sensors can map the equilibrium structure of these knots between tight and loose states. |
| url |
https://doi.org/10.1038/s41467-019-12358-4 |
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