In a model of Batten disease, palmitoyl protein thioesterase-1 deficiency is associated with brown adipose tissue and thermoregulation abnormalities.
Infantile neuronal ceroid lipofuscinosis (INCL) is a fatal neurodegenerative disorder caused by a deficiency of palmitoyl-protein thioesterase-1 (PPT1). We have previously shown that children with INCL have increased risk of hypothermia during anesthesia and that PPT1-deficiency in mice is associate...
Main Authors: | Alfia Khaibullina, Nicholas Kenyon, Virginia Guptill, Martha M Quezado, Li Wang, Deloris Koziol, Robert Wesley, Pablo R Moya, Zhongjian Zhang, Arjun Saha, Anil B Mukherjee, Zenaide M N Quezado |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3490854?pdf=render |
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