Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates

• Main Author: Ramesh N. Patel
• Format: Article
• Language: English
• Published: University of Zagreb 2004-01-01
• Series: Food Technology and Biotechnology
• Subjects: biocatalysis; chiral intermediates; anticancer; antihypertensive; anti-infective; enantioselective enzymatic de-protection
• Online Access: http://hrcak.srce.hr/file/163397

The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral pharmaceutical intermediates.