Tissue plasminogen activator in brain tissues infected with transmissible spongiform encephalopathies

Tissue plasminogen activator in brain tissues infected with transmissible spongiform encephalopathies

Prion propagation involves conversion of host PrPC to a disease-related isoform, PrPSc, which accumulates during disease and is the principal component of the transmissible agent. Proteolysis seems to play an important role in PrP metabolism. Plasminogen, a serine protease precursor, has been shown...

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Bibliographic Details
Main Authors: K. Xanthopoulos, I. Paspaltsis, V. Apostolidou, S. Petrakis, C.J. Siao, A. Kalpatsanidis, N. Grigoriadis, A. Tsaftaris, S.E. Tsirka, T. Sklaviadis
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
tPA
Plasminogen
PrP
TSE
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001269

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