Macrophage, the potential key mediator in CAR-T related CRS

Macrophage, the potential key mediator in CAR-T related CRS

Abstract Chimeric antigen receptor (CAR) T cell therapy is a new frontier in cancer therapy. The toxicity of cytokine release syndrome (CRS) has become one of the major challenges that limits the wider use of CAR T cells to fight cancer. Exploration of CRS pathogenesis and treatment is becoming the...

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Bibliographic Details
Main Authors: Zhaonian Hao, Ruyuan Li, Li Meng, Zhiqiang Han, Zhenya Hong
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Experimental Hematology & Oncology
Subjects:
Chimeric antigen receptor T cell therapy
Cytokine release syndrome
Macrophage
Online Access:http://link.springer.com/article/10.1186/s40164-020-00171-5

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