High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009
Human bocavirus (HBoV) is a parvovirus whose association with respiratory disease is currently under investigation. Objective: To determine HBoV prevalence in children with lower acute respiratory infection. Methods: We investigated HBoV in 433 nasopharyngeal aspirates collected in 2007–2009 from ch...
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doaj-2b2efd18b7f9481799e4c1a6988afdcd2020-11-25T03:04:44ZengElsevierBrazilian Journal of Infectious Diseases1413-86702012-01-011613844High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009Lucía María Ghietto0Alicia Cámara1Yumei Zhou2Mauro Pedranti3Silvia Ferreyra4Teryl Frey5Jorge Cámara6Maria Pilar Adamo7Instituto de Virología “Dr. J.M. Vanella”, Medical School, Universidad Nacional de Córdoba, ArgentinaInstituto de Virología “Dr. J.M. Vanella”, Medical School, Universidad Nacional de Córdoba, ArgentinaDepartment of Biology, Georgia State University, Atlanta, USAInstituto de Virología “Dr. J.M. Vanella”, Medical School, Universidad Nacional de Córdoba, ArgentinaHospital Pediátrico de Córdoba, ArgentinaDepartment of Biology, Georgia State University, Atlanta, USAInstituto de Virología “Dr. J.M. Vanella”, Medical School, Universidad Nacional de Córdoba, ArgentinaInstituto de Virología “Dr. J.M. Vanella”, Medical School, Universidad Nacional de Córdoba, Argentina; Corresponding author at: Calle Enf. Grodillo Gómez S/N, Ciudad Universitaria, CP 5016, Córdoba, Argentina.Human bocavirus (HBoV) is a parvovirus whose association with respiratory disease is currently under investigation. Objective: To determine HBoV prevalence in children with lower acute respiratory infection. Methods: We investigated HBoV in 433 nasopharyngeal aspirates collected in 2007–2009 from children 0 to 5 years old hospitalized with bronchiolitis or pneumonia in Córdoba, Argentina. Results: The general prevalence of HBoV was 21.5% and the positive cases (HBoV+) were more frequent during winter and spring. The mean age of HBoV+ patients was 6.9 months, with 87.1% of the detections corresponding to infants less than 1 year old (among which the prevalence of HBoV was 26.3% in patients < 3 months of age, 22.1% in 3 to 6 months, 25.3% in 6 to 9 months, and 18.8% in 9 to 12 months). The sequence analysis of the NP1 coding region of 15 isolates showed that all isolates from Cordoba were HBoV1 which exhibited a homology of nearly 100% both among themselves and with the originally discovered virus from 2005. Conclusion: Overall, our results indicate that HBoV is a significant pathogen that contributes to acute respiratory infection both on its own and during coinfection with other viruses. Keywords: Human bocavirus 1, Infant, Bronchiolitis, Pneumoniahttp://www.sciencedirect.com/science/article/pii/S1413867012702726 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucía María Ghietto Alicia Cámara Yumei Zhou Mauro Pedranti Silvia Ferreyra Teryl Frey Jorge Cámara Maria Pilar Adamo |
spellingShingle |
Lucía María Ghietto Alicia Cámara Yumei Zhou Mauro Pedranti Silvia Ferreyra Teryl Frey Jorge Cámara Maria Pilar Adamo High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009 Brazilian Journal of Infectious Diseases |
author_facet |
Lucía María Ghietto Alicia Cámara Yumei Zhou Mauro Pedranti Silvia Ferreyra Teryl Frey Jorge Cámara Maria Pilar Adamo |
author_sort |
Lucía María Ghietto |
title |
High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009 |
title_short |
High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009 |
title_full |
High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009 |
title_fullStr |
High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009 |
title_full_unstemmed |
High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 – 2009 |
title_sort |
high prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in argentina, 2007 – 2009 |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2012-01-01 |
description |
Human bocavirus (HBoV) is a parvovirus whose association with respiratory disease is currently under investigation. Objective: To determine HBoV prevalence in children with lower acute respiratory infection. Methods: We investigated HBoV in 433 nasopharyngeal aspirates collected in 2007–2009 from children 0 to 5 years old hospitalized with bronchiolitis or pneumonia in Córdoba, Argentina. Results: The general prevalence of HBoV was 21.5% and the positive cases (HBoV+) were more frequent during winter and spring. The mean age of HBoV+ patients was 6.9 months, with 87.1% of the detections corresponding to infants less than 1 year old (among which the prevalence of HBoV was 26.3% in patients < 3 months of age, 22.1% in 3 to 6 months, 25.3% in 6 to 9 months, and 18.8% in 9 to 12 months). The sequence analysis of the NP1 coding region of 15 isolates showed that all isolates from Cordoba were HBoV1 which exhibited a homology of nearly 100% both among themselves and with the originally discovered virus from 2005. Conclusion: Overall, our results indicate that HBoV is a significant pathogen that contributes to acute respiratory infection both on its own and during coinfection with other viruses. Keywords: Human bocavirus 1, Infant, Bronchiolitis, Pneumonia |
url |
http://www.sciencedirect.com/science/article/pii/S1413867012702726 |
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