Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review
Background: Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes. Hydrogen sulfide (H2S), a novel gasotransmitter, is found to play important roles in regulation of glucose metabolism homeostasis. Aim of Review: T...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
|
Series: | Journal of Advanced Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123220300370 |
id |
doaj-2b35c0eedf2d4e93989737f736b79f6a |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heng Zhang Yaqian Huang Selena Chen Chaoshu Tang Guang Wang Junbao Du Hongfang Jin |
spellingShingle |
Heng Zhang Yaqian Huang Selena Chen Chaoshu Tang Guang Wang Junbao Du Hongfang Jin Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review Journal of Advanced Research Hydrogen sulfide Diabetes mellitus Insulin resistance Cystathionine γ-lyase Cystathionine β-synthase |
author_facet |
Heng Zhang Yaqian Huang Selena Chen Chaoshu Tang Guang Wang Junbao Du Hongfang Jin |
author_sort |
Heng Zhang |
title |
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review |
title_short |
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review |
title_full |
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review |
title_fullStr |
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review |
title_full_unstemmed |
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review |
title_sort |
hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? a review |
publisher |
Elsevier |
series |
Journal of Advanced Research |
issn |
2090-1232 |
publishDate |
2021-01-01 |
description |
Background: Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes. Hydrogen sulfide (H2S), a novel gasotransmitter, is found to play important roles in regulation of glucose metabolism homeostasis. Aim of Review: This study aimed to summarize and discuss current data about the function of H2S in insulin secretion and insulin resistance regulation as well as the underlying mechanisms. Key Scientific Concepts of Review: H2S could be endogenously produced in islet β cells, liver, adipose, skeletal muscles, and the hypothalamus, and regulates local and systemic glucose metabolism. It is reported that H2S suppresses insulin secretion, promotes or reduces the apoptosis of islet β cells. It plays important roles in the regulation of insulin sensitivity in insulin responsive tissues. H2S inhibits glucose uptake and glycogen storage, and promotes or inhibits gluconeogenesis, mitochondrial biogenesis and mitochondrial bioenergetics in the liver. In adipose tissue, several investigators indicated that H2S promoted glucose uptake in adipocytes, while other studies reported that H2S inhibits this process. H2S has also been shown to promote adipogenesis, inhibit lipolysis, and regulate adiponectin and MCP-1 secretion from adipocytes. In skeletal muscle, H2S increases glucose uptake and improves insulin sensitivity. It is also observed that H2S modulates circadian-clock genes in muscle. Hypothalamic CBS/H2S pathway reduces obesity and improves insulin sensitivity via the brain-adipose interaction. Most studies indicated plasma H2S levels decreased in diabetic patients. However, the mechanisms by which H2S regulates systemic glucose metabolism remain unclear. Whether H2S acts as a new promising target for diabetes mellitus treatment merits further studies. |
topic |
Hydrogen sulfide Diabetes mellitus Insulin resistance Cystathionine γ-lyase Cystathionine β-synthase |
url |
http://www.sciencedirect.com/science/article/pii/S2090123220300370 |
work_keys_str_mv |
AT hengzhang hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview AT yaqianhuang hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview AT selenachen hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview AT chaoshutang hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview AT guangwang hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview AT junbaodu hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview AT hongfangjin hydrogensulfideregulatesinsulinsecretionandinsulinresistanceindiabetesmellitusanewpromisingtargetfordiabetesmellitustreatmentareview |
_version_ |
1724386880930185216 |
spelling |
doaj-2b35c0eedf2d4e93989737f736b79f6a2020-12-11T04:20:49ZengElsevierJournal of Advanced Research2090-12322021-01-01271930Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A reviewHeng Zhang0Yaqian Huang1Selena Chen2Chaoshu Tang3Guang Wang4Junbao Du5Hongfang Jin6Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China; Research Unit of Clinical Diagnosis and Treatment of Pediatric Syncope and Cardiovascular Diseases, Chinese Academy of Medical Sciences, ChinaDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, United StatesDepartment of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing 100091, China; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100083, ChinaDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; Corresponding authors at: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China (J. Du and H. Jin).Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; Research Unit of Clinical Diagnosis and Treatment of Pediatric Syncope and Cardiovascular Diseases, Chinese Academy of Medical Sciences, China; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100083, China; Corresponding authors at: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China (J. Du and H. Jin).Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; Research Unit of Clinical Diagnosis and Treatment of Pediatric Syncope and Cardiovascular Diseases, Chinese Academy of Medical Sciences, China; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100083, China; Corresponding authors at: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China (J. Du and H. Jin).Background: Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes. Hydrogen sulfide (H2S), a novel gasotransmitter, is found to play important roles in regulation of glucose metabolism homeostasis. Aim of Review: This study aimed to summarize and discuss current data about the function of H2S in insulin secretion and insulin resistance regulation as well as the underlying mechanisms. Key Scientific Concepts of Review: H2S could be endogenously produced in islet β cells, liver, adipose, skeletal muscles, and the hypothalamus, and regulates local and systemic glucose metabolism. It is reported that H2S suppresses insulin secretion, promotes or reduces the apoptosis of islet β cells. It plays important roles in the regulation of insulin sensitivity in insulin responsive tissues. H2S inhibits glucose uptake and glycogen storage, and promotes or inhibits gluconeogenesis, mitochondrial biogenesis and mitochondrial bioenergetics in the liver. In adipose tissue, several investigators indicated that H2S promoted glucose uptake in adipocytes, while other studies reported that H2S inhibits this process. H2S has also been shown to promote adipogenesis, inhibit lipolysis, and regulate adiponectin and MCP-1 secretion from adipocytes. In skeletal muscle, H2S increases glucose uptake and improves insulin sensitivity. It is also observed that H2S modulates circadian-clock genes in muscle. Hypothalamic CBS/H2S pathway reduces obesity and improves insulin sensitivity via the brain-adipose interaction. Most studies indicated plasma H2S levels decreased in diabetic patients. However, the mechanisms by which H2S regulates systemic glucose metabolism remain unclear. Whether H2S acts as a new promising target for diabetes mellitus treatment merits further studies.http://www.sciencedirect.com/science/article/pii/S2090123220300370Hydrogen sulfideDiabetes mellitusInsulin resistanceCystathionine γ-lyaseCystathionine β-synthase |