Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

<p>Abstract</p> <p>Background</p> <p>Mutations in the substrate of HIV-1 protease, especially changes in the NC/p1 cleavage site, can directly contribute to protease inhibitor (PI) resistance and also compensate for defects in viral replicative capacity (RC) due to a dr...

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Bibliographic Details
Main Authors: van Maarseveen Noortje M, Andersson Dan, Lepšík Martin, Fun Axel, Schipper Pauline J, de Jong Dorien, Boucher Charles AB, Nijhuis Monique
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Retrovirology
Subjects:
HIV-1
Protease
Resistance
Gag
Cleavage
Replicative capacity
NC/p1
Online Access:http://www.retrovirology.com/content/9/1/29

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