Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years
Abstract Introduction On the basis of the proxy measures of cognitive reserve, we created a middle age self‐report risk score for early prediction of dementia. Methods We used a longitudinal population‐based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2016.08.003 |
| Summary: | Abstract Introduction On the basis of the proxy measures of cognitive reserve, we created a middle age self‐report risk score for early prediction of dementia. Methods We used a longitudinal population‐based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments. Results The prevalence of dementia was 10% after a mean follow‐up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow‐up of 39 years in the replication sample. Discussion Self‐report risk score predicted cognitive functioning and dementia risk 20–40 years later. |
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| ISSN: | 2352-8729 |