Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhib...

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Main Authors: Jan M. Schulz, Frederic Knoflach, Maria-Clemencia Hernandez, Josef Bischofberger
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06004-8
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spelling doaj-2b44f2781de8400fa51141e60c25aa5b2021-05-11T10:32:14ZengNature Publishing GroupNature Communications2041-17232018-09-019111610.1038/s41467-018-06004-8Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptorsJan M. Schulz0Frederic Knoflach1Maria-Clemencia Hernandez2Josef Bischofberger3Department of Biomedicine, University of BaselPharma Research and Early Development, Discovery Neuroscience Department, F. Hoffmann-La Roche LtdPharma Research and Early Development, Discovery Neuroscience Department, F. Hoffmann-La Roche LtdDepartment of Biomedicine, University of BaselSomatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhibition with slow gating kinetics matches voltage and time-dependent activation of synaptic NMDARs, thereby controlling the generation of dendritic NMDA spikes.https://doi.org/10.1038/s41467-018-06004-8
collection DOAJ
language English
format Article
sources DOAJ
author Jan M. Schulz
Frederic Knoflach
Maria-Clemencia Hernandez
Josef Bischofberger
spellingShingle Jan M. Schulz
Frederic Knoflach
Maria-Clemencia Hernandez
Josef Bischofberger
Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
Nature Communications
author_facet Jan M. Schulz
Frederic Knoflach
Maria-Clemencia Hernandez
Josef Bischofberger
author_sort Jan M. Schulz
title Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_short Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_full Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_fullStr Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_full_unstemmed Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_sort dendrite-targeting interneurons control synaptic nmda-receptor activation via nonlinear α5-gabaa receptors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhibition with slow gating kinetics matches voltage and time-dependent activation of synaptic NMDARs, thereby controlling the generation of dendritic NMDA spikes.
url https://doi.org/10.1038/s41467-018-06004-8
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AT mariaclemenciahernandez dendritetargetinginterneuronscontrolsynapticnmdareceptoractivationvianonlineara5gabaareceptors
AT josefbischofberger dendritetargetinginterneuronscontrolsynapticnmdareceptoractivationvianonlineara5gabaareceptors
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