Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment
Introduction: Oral metastases are rare and represent 1% oro-facial neoplasms. The lung is the most common primary site for oral metastatic tumors. The diagnosis is based on histological analysis. Oral metastases have been associated with poor prognosis and is no longer a proven treatment. It was fou...
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doaj-2b4b4eedc598426ba6c4180604454bad2021-04-02T12:53:45ZengEDP SciencesJournal of Oral Medicine and Oral Surgery2608-13262019-01-01251910.1051/mbcb/2018026mbcb180034Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatmentPicot Etienne0Jouan Robin1Bach Emma2Murcier Gregory3Borgnat Florent4Maxillofacial Surgery Department, North West HospitalMaxillofacial Surgery Department, North West HospitalMaxillofacial Surgery Department, North West HospitalMaxillofacial Surgery Department, North West HospitalMaxillofacial Surgery Department, North West HospitalIntroduction: Oral metastases are rare and represent 1% oro-facial neoplasms. The lung is the most common primary site for oral metastatic tumors. The diagnosis is based on histological analysis. Oral metastases have been associated with poor prognosis and is no longer a proven treatment. It was found in a 58-year old man diagnosed with lung cancer with a voluminous mandibular tumefaction following dental avulsion. The panoramic X-ray showed an area of osteolysis compared to the extraction site. The histological and immunohistochemistry of the lesion showed a positivity of the marker CK7 and a negativity of TTF1, in favor of a lung origin. The biomolecular analysis revealed a mutation on the BRAF gene confirming the metastasis primitive origin. Treatment by surgical resection was performed palliatively. Comments: The diagnosis of an oral metastasis remains difficult and is based on the histological analysis and finding immune markers. Molecular biology is sometimes required for theranostics. Treatment options include surgical resection, radiotherapy, and/or chemotherapy. They are sometimes limited to preserve the quality of life. The prognosis of patients with oral metastases is very poor. Conclusion: Oral metastases are rare, and the diagnosis remains difficult.https://www.jomos.org/articles/mbcb/full_html/2019/01/mbcb180034/mbcb180034.htmloral metastasislung canceradenocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Picot Etienne Jouan Robin Bach Emma Murcier Gregory Borgnat Florent |
spellingShingle |
Picot Etienne Jouan Robin Bach Emma Murcier Gregory Borgnat Florent Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment Journal of Oral Medicine and Oral Surgery oral metastasis lung cancer adenocarcinoma |
author_facet |
Picot Etienne Jouan Robin Bach Emma Murcier Gregory Borgnat Florent |
author_sort |
Picot Etienne |
title |
Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment |
title_short |
Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment |
title_full |
Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment |
title_fullStr |
Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment |
title_full_unstemmed |
Oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment |
title_sort |
oral metastasis of pulmonary adenocarcinoma: diagnosis and treatment |
publisher |
EDP Sciences |
series |
Journal of Oral Medicine and Oral Surgery |
issn |
2608-1326 |
publishDate |
2019-01-01 |
description |
Introduction: Oral metastases are rare and represent 1% oro-facial neoplasms. The lung is the most common primary site for oral metastatic tumors. The diagnosis is based on histological analysis. Oral metastases have been associated with poor prognosis and is no longer a proven treatment. It was found in a 58-year old man diagnosed with lung cancer with a voluminous mandibular tumefaction following dental avulsion. The panoramic X-ray showed an area of osteolysis compared to the extraction site. The histological and immunohistochemistry of the lesion showed a positivity of the marker CK7 and a negativity of TTF1, in favor of a lung origin. The biomolecular analysis revealed a mutation on the BRAF gene confirming the metastasis primitive origin. Treatment by surgical resection was performed palliatively. Comments: The diagnosis of an oral metastasis remains difficult and is based on the histological analysis and finding immune markers. Molecular biology is sometimes required for theranostics. Treatment options include surgical resection, radiotherapy, and/or chemotherapy. They are sometimes limited to preserve the quality of life. The prognosis of patients with oral metastases is very poor. Conclusion: Oral metastases are rare, and the diagnosis remains difficult. |
topic |
oral metastasis lung cancer adenocarcinoma |
url |
https://www.jomos.org/articles/mbcb/full_html/2019/01/mbcb180034/mbcb180034.html |
work_keys_str_mv |
AT picotetienne oralmetastasisofpulmonaryadenocarcinomadiagnosisandtreatment AT jouanrobin oralmetastasisofpulmonaryadenocarcinomadiagnosisandtreatment AT bachemma oralmetastasisofpulmonaryadenocarcinomadiagnosisandtreatment AT murciergregory oralmetastasisofpulmonaryadenocarcinomadiagnosisandtreatment AT borgnatflorent oralmetastasisofpulmonaryadenocarcinomadiagnosisandtreatment |
_version_ |
1721567286356082688 |