Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties
A series of new sulfone compounds containing 1,3,4-oxadiazole moieties were synthesized. The structures of these compounds were confirmed by spectroscopic data (IR, 1H- and 13C-NMR) and elemental analyses. Antifungal tests indicated that all the title compounds exhibited good antifungal activities a...
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doaj-2b50ec7844914a1d901827771ac8746a2020-11-25T00:27:58ZengMDPI AGMolecules1420-30492011-11-0116119129914110.3390/molecules16119129Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole MoietiesMaoguo TongJian WangZhaoxi PanFeifei HanXuehai ChenMing HeJiang HeWeiming XuA series of new sulfone compounds containing 1,3,4-oxadiazole moieties were synthesized. The structures of these compounds were confirmed by spectroscopic data (IR, 1H- and 13C-NMR) and elemental analyses. Antifungal tests indicated that all the title compounds exhibited good antifungal activities against eight kinds of plant pathogenic fungi, and some showed superiority over the commercial fungicide hymexazol. Among them, compounds 5d, 5e, 5f, and 5i showed prominent activity against B. cinerea, with determined EC50 values of 5.21 μg/mL, 8.25 µg/mL, 8.03 µg/mL, and 21.00 µg/mL, respectively. The present work demonstrates that sulfone derivatives such as 5d containing a 1,3,4-oxadiazole moiety can be used as possible lead compounds for the development of potential agrochemicals.http://www.mdpi.com/1420-3049/16/11/9129/sulfoneoxadiazoleantifungal activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maoguo Tong Jian Wang Zhaoxi Pan Feifei Han Xuehai Chen Ming He Jiang He Weiming Xu |
spellingShingle |
Maoguo Tong Jian Wang Zhaoxi Pan Feifei Han Xuehai Chen Ming He Jiang He Weiming Xu Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties Molecules sulfone oxadiazole antifungal activity |
author_facet |
Maoguo Tong Jian Wang Zhaoxi Pan Feifei Han Xuehai Chen Ming He Jiang He Weiming Xu |
author_sort |
Maoguo Tong |
title |
Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties |
title_short |
Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties |
title_full |
Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties |
title_fullStr |
Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties |
title_full_unstemmed |
Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties |
title_sort |
synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2011-11-01 |
description |
A series of new sulfone compounds containing 1,3,4-oxadiazole moieties were synthesized. The structures of these compounds were confirmed by spectroscopic data (IR, 1H- and 13C-NMR) and elemental analyses. Antifungal tests indicated that all the title compounds exhibited good antifungal activities against eight kinds of plant pathogenic fungi, and some showed superiority over the commercial fungicide hymexazol. Among them, compounds 5d, 5e, 5f, and 5i showed prominent activity against B. cinerea, with determined EC50 values of 5.21 μg/mL, 8.25 µg/mL, 8.03 µg/mL, and 21.00 µg/mL, respectively. The present work demonstrates that sulfone derivatives such as 5d containing a 1,3,4-oxadiazole moiety can be used as possible lead compounds for the development of potential agrochemicals. |
topic |
sulfone oxadiazole antifungal activity |
url |
http://www.mdpi.com/1420-3049/16/11/9129/ |
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