B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling domains and B7-expressing antigen presenting cells...

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Bibliographic Details
Main Authors: Masashi Watanabe, Ying Lu, Michael Breen, Richard J. Hodes
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20070-x
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spelling doaj-2b526663f7e1461c91c46d55318b21892021-01-31T13:38:20ZengNature Publishing GroupNature Communications2041-17232020-12-0111111410.1038/s41467-020-20070-xB7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanismsMasashi Watanabe0Ying Lu1Michael Breen2Richard J. Hodes3Experimental Immunology Branch, National Cancer InstituteExperimental Immunology Branch, National Cancer InstituteExperimental Immunology Branch, National Cancer InstituteExperimental Immunology Branch, National Cancer InstituteB7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling domains and B7-expressing antigen presenting cells mediating these two processes.https://doi.org/10.1038/s41467-020-20070-x
collection DOAJ
language English
format Article
sources DOAJ
author Masashi Watanabe
Ying Lu
Michael Breen
Richard J. Hodes
spellingShingle Masashi Watanabe
Ying Lu
Michael Breen
Richard J. Hodes
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
Nature Communications
author_facet Masashi Watanabe
Ying Lu
Michael Breen
Richard J. Hodes
author_sort Masashi Watanabe
title B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_short B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_full B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_fullStr B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_full_unstemmed B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_sort b7-cd28 co-stimulation modulates central tolerance via thymic clonal deletion and treg generation through distinct mechanisms
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-12-01
description B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling domains and B7-expressing antigen presenting cells mediating these two processes.
url https://doi.org/10.1038/s41467-020-20070-x
work_keys_str_mv AT masashiwatanabe b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
AT yinglu b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
AT michaelbreen b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
AT richardjhodes b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
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