Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies
Abstract Background Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management. Methods We systematically searched the medical literature to identify abstracts of interest indexed between 194...
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doaj-2b56e802801f4128be2881f03ee055d52020-11-24T22:14:52ZengBMCOrphanet Journal of Rare Diseases1750-11722018-05-011311910.1186/s13023-018-0815-5Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studiesEmel Aygören-Pürsün0Markus Magerl1Andreas Maetzel2Marcus Maurer3Department for Children and Adolescents, University Hospital FrankfurtDepartment of Dermatology and Allergy, Charité – Universitätsmedizin BerlinInstitute of Health Policy, Management & Evaluation, University of TorontoDepartment of Dermatology and Allergy, Charité – Universitätsmedizin BerlinAbstract Background Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management. Methods We systematically searched the medical literature to identify abstracts of interest indexed between 1948 and March, 2016. We used published national survey data on the proportion of the population treated with angiotensin-converting enzyme inhibitors (ACEI) to derive estimates of the population prevalence of ACEI-AE in the USA, Germany and France. For hereditary angioedema (C1-INH-HAE) and C1-inhibitor related acquired angioedema (C1-INH-AAE), publications had to contain original epidemiologic data collection within a defined geographical area. Hereditary angioedema with normal C1-INH was not included in the analysis due to lack of clearly defined criteria. Results We identified 4 relevant publications on the prevalence of ACEI-AE, 6 on the prevalence of C1-INH-HAE, and 1 on the prevalence of C1-INH-AAE. The 1st year cumulative incidence of ACEI-AE was estimated to vary between 0.12 (population-based analyses) and 0.30 (meta-analyses of clinical trials) per 100 patient-years. The population prevalence of ACEI-AE was modeled to vary between 7 and 26 in 100,000. The prevalence of C1-INH-HAE was estimated to vary between 1.1 and 1.6 per 100,000. The prevalence of C1-INH-AAE was estimated to be 0.15 per 100,000 in one epidemiological investigation of AAE in Denmark. Conclusions Epidemiological evidence on Bk-AE is limited to North America and Europe. ACEI-AE is more common than C1-INH-HAE (~ 10:1), which is more common than C1-INH-AAE (~ 10:1). More studies are needed to comprehensively assess the epidemiological burden of Bk-AE.http://link.springer.com/article/10.1186/s13023-018-0815-5AngioedemaBradykininEpidemiologyC1-inhibitorACE-inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emel Aygören-Pürsün Markus Magerl Andreas Maetzel Marcus Maurer |
spellingShingle |
Emel Aygören-Pürsün Markus Magerl Andreas Maetzel Marcus Maurer Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies Orphanet Journal of Rare Diseases Angioedema Bradykinin Epidemiology C1-inhibitor ACE-inhibitor |
author_facet |
Emel Aygören-Pürsün Markus Magerl Andreas Maetzel Marcus Maurer |
author_sort |
Emel Aygören-Pürsün |
title |
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies |
title_short |
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies |
title_full |
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies |
title_fullStr |
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies |
title_full_unstemmed |
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies |
title_sort |
epidemiology of bradykinin-mediated angioedema: a systematic investigation of epidemiological studies |
publisher |
BMC |
series |
Orphanet Journal of Rare Diseases |
issn |
1750-1172 |
publishDate |
2018-05-01 |
description |
Abstract Background Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management. Methods We systematically searched the medical literature to identify abstracts of interest indexed between 1948 and March, 2016. We used published national survey data on the proportion of the population treated with angiotensin-converting enzyme inhibitors (ACEI) to derive estimates of the population prevalence of ACEI-AE in the USA, Germany and France. For hereditary angioedema (C1-INH-HAE) and C1-inhibitor related acquired angioedema (C1-INH-AAE), publications had to contain original epidemiologic data collection within a defined geographical area. Hereditary angioedema with normal C1-INH was not included in the analysis due to lack of clearly defined criteria. Results We identified 4 relevant publications on the prevalence of ACEI-AE, 6 on the prevalence of C1-INH-HAE, and 1 on the prevalence of C1-INH-AAE. The 1st year cumulative incidence of ACEI-AE was estimated to vary between 0.12 (population-based analyses) and 0.30 (meta-analyses of clinical trials) per 100 patient-years. The population prevalence of ACEI-AE was modeled to vary between 7 and 26 in 100,000. The prevalence of C1-INH-HAE was estimated to vary between 1.1 and 1.6 per 100,000. The prevalence of C1-INH-AAE was estimated to be 0.15 per 100,000 in one epidemiological investigation of AAE in Denmark. Conclusions Epidemiological evidence on Bk-AE is limited to North America and Europe. ACEI-AE is more common than C1-INH-HAE (~ 10:1), which is more common than C1-INH-AAE (~ 10:1). More studies are needed to comprehensively assess the epidemiological burden of Bk-AE. |
topic |
Angioedema Bradykinin Epidemiology C1-inhibitor ACE-inhibitor |
url |
http://link.springer.com/article/10.1186/s13023-018-0815-5 |
work_keys_str_mv |
AT emelaygorenpursun epidemiologyofbradykininmediatedangioedemaasystematicinvestigationofepidemiologicalstudies AT markusmagerl epidemiologyofbradykininmediatedangioedemaasystematicinvestigationofepidemiologicalstudies AT andreasmaetzel epidemiologyofbradykininmediatedangioedemaasystematicinvestigationofepidemiologicalstudies AT marcusmaurer epidemiologyofbradykininmediatedangioedemaasystematicinvestigationofepidemiologicalstudies |
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