MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice

Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.

Bibliographic Details
Main Authors:	Keerthi Krishnan, Billy Y. B. Lau, Gabrielle Ewall, Z. Josh Huang, Stephen D. Shea
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14077

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spelling	doaj-2b5895d8e4a14e788bb12e1a4e851f722021-05-11T07:42:17ZengNature Publishing GroupNature Communications2041-17232017-01-018111310.1038/ncomms14077MECP2 regulates cortical plasticity underlying a learned behaviour in adult female miceKeerthi Krishnan0Billy Y. B. Lau1Gabrielle Ewall2Z. Josh Huang3Stephen D. Shea4Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring HarborCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring HarborCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring HarborCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring HarborCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring HarborRett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.https://doi.org/10.1038/ncomms14077
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Keerthi Krishnan Billy Y. B. Lau Gabrielle Ewall Z. Josh Huang Stephen D. Shea
spellingShingle	Keerthi Krishnan Billy Y. B. Lau Gabrielle Ewall Z. Josh Huang Stephen D. Shea MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice Nature Communications
author_facet	Keerthi Krishnan Billy Y. B. Lau Gabrielle Ewall Z. Josh Huang Stephen D. Shea
author_sort	Keerthi Krishnan
title	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_short	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_full	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_fullStr	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_full_unstemmed	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_sort	mecp2 regulates cortical plasticity underlying a learned behaviour in adult female mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-01-01
description	Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.
url	https://doi.org/10.1038/ncomms14077
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MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice

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