Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study
Objective. To explore acupuncture effects on brain functional connectivity in patients with functional dyspepsia (FD). Methods. Eight patients in an acupuncture treatment group and ten healthy adults in the control group participated in the study. Acupuncture effectiveness was evaluated based on cha...
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doaj-2b67ae08f4a74f99a8a7330e12fd6b8f2020-11-24T22:34:18ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/860463860463Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI StudyJiliang Fang0Danhong Wang1Qing Zhao2Yang Hong3Yulian Jin4Zhishun Liu5Kehua Zhou6Xianghong Jing7Xiaochun Yu8Ruiqi Pan9Andrew Chang10Hesheng Liu11Bing Zhu12Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USADepartment of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Health Care Studies, Daemen College, Amherst, NY 14226, USAInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USADepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USAMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USAInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaObjective. To explore acupuncture effects on brain functional connectivity in patients with functional dyspepsia (FD). Methods. Eight patients in an acupuncture treatment group and ten healthy adults in the control group participated in the study. Acupuncture effectiveness was evaluated based on changes of the gastrointestinal symptoms, gastric motility measurements, and gastrin levels and comparisons with the control group when appropriate. To investigate functional connectivity changes related to FD and potential modulation after acupuncture, a set of regions of interest (ROIs) were selected according to previous fMRI reports of acupuncture. Results. Patients showed significant improvements of FD signs and symptoms after acupuncture treatments. For all of the ROIs, we identified subportions of the networks showing reduced connectivity in patients with FD. Connectivity between the ROIs and corresponding disease targets showed significant improvement after acupuncture treatment (P<0.05) in all ROIs except for right medial temporal lobe-hippocampus and right inferior parietal lobule. Conclusion. Functional connectivity of the brain is changed in patients with FD but approximates that in healthy control after acupuncture treatment. The relief of gastrointestinal signs and symptoms by acupuncture is likely due to the normalization of brain-gut axis associated with FD.http://dx.doi.org/10.1155/2015/860463 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiliang Fang Danhong Wang Qing Zhao Yang Hong Yulian Jin Zhishun Liu Kehua Zhou Xianghong Jing Xiaochun Yu Ruiqi Pan Andrew Chang Hesheng Liu Bing Zhu |
spellingShingle |
Jiliang Fang Danhong Wang Qing Zhao Yang Hong Yulian Jin Zhishun Liu Kehua Zhou Xianghong Jing Xiaochun Yu Ruiqi Pan Andrew Chang Hesheng Liu Bing Zhu Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study Evidence-Based Complementary and Alternative Medicine |
author_facet |
Jiliang Fang Danhong Wang Qing Zhao Yang Hong Yulian Jin Zhishun Liu Kehua Zhou Xianghong Jing Xiaochun Yu Ruiqi Pan Andrew Chang Hesheng Liu Bing Zhu |
author_sort |
Jiliang Fang |
title |
Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study |
title_short |
Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study |
title_full |
Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study |
title_fullStr |
Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study |
title_full_unstemmed |
Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study |
title_sort |
brain-gut axis modulation of acupuncture in functional dyspepsia: a preliminary resting-state fcmri study |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
Objective. To explore acupuncture effects on brain functional connectivity in patients with functional dyspepsia (FD). Methods. Eight patients in an acupuncture treatment group and ten healthy adults in the control group participated in the study. Acupuncture effectiveness was evaluated based on changes of the gastrointestinal symptoms, gastric motility measurements, and gastrin levels and comparisons with the control group when appropriate. To investigate functional connectivity changes related to FD and potential modulation after acupuncture, a set of regions of interest (ROIs) were selected according to previous fMRI reports of acupuncture. Results. Patients showed significant improvements of FD signs and symptoms after acupuncture treatments. For all of the ROIs, we identified subportions of the networks showing reduced connectivity in patients with FD. Connectivity between the ROIs and corresponding disease targets showed significant improvement after acupuncture treatment (P<0.05) in all ROIs except for right medial temporal lobe-hippocampus and right inferior parietal lobule. Conclusion. Functional connectivity of the brain is changed in patients with FD but approximates that in healthy control after acupuncture treatment. The relief of gastrointestinal signs and symptoms by acupuncture is likely due to the normalization of brain-gut axis associated with FD. |
url |
http://dx.doi.org/10.1155/2015/860463 |
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