Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease

Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease

Fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the United States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; how...

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Main Authors: Tianhao Zhou, Debjyoti Kundu, Jonathan Robles-Linares, Vik Meadows, Keisaku Sato, Leonardo Baiocchi, Burcin Ekser, Shannon Glaser, Gianfranco Alpini, Heather Francis, Lindsey Kennedy
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
cholangiocytes
bile acids
cholestatic liver disease
ductular reaction
non-alcoholic fatty liver disease
Online Access:https://www.mdpi.com/2073-4409/10/8/2072
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spelling doaj-2b67eb55e8404cd28a097a47095021792021-08-26T13:37:35ZengMDPI AGCells2073-44092021-08-01102072207210.3390/cells10082072Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver DiseaseTianhao Zhou0Debjyoti Kundu1Jonathan Robles-Linares2Vik Meadows3Keisaku Sato4Leonardo Baiocchi5Burcin Ekser6Shannon Glaser7Gianfranco Alpini8Heather Francis9Lindsey Kennedy10Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USADivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Graduate Studies, Indiana University School of Medicine, Indianapolis, IN 46202, USADivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USADivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USALiver Unit, Department of Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDivision of Transplant Surgery, Department of Surgery, Indiana University, Indianapolis, IN 46202, USADepartment of Medical Physiology, Texas A&M University College of Medicine Bryan, Bryan, TX 77807, USADivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USADivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USADivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USAFatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the United States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; however, the impact of other biliary epithelial cells (i.e., cholangiocytes) in the promotion of NAFLD is growing. This review article will discuss how cholestatic injury and cholangiocyte activity/ductular reaction influence NAFLD progression. Furthermore, this review will provide informative details regarding the fundamental properties of cholangiocytes and bile acid signaling that can influence NAFLD. Lastly, studies relating to the pathogenesis of NAFLD, cholangiopathies, and ductular reaction will be analyzed to help gain insight for potential therapies.https://www.mdpi.com/2073-4409/10/8/2072cholangiocytesbile acidscholestatic liver diseaseductular reactionnon-alcoholic fatty liver disease
collection DOAJ
language English
format Article
sources DOAJ
author Tianhao Zhou
Debjyoti Kundu
Jonathan Robles-Linares
Vik Meadows
Keisaku Sato
Leonardo Baiocchi
Burcin Ekser
Shannon Glaser
Gianfranco Alpini
Heather Francis
Lindsey Kennedy
spellingShingle Tianhao Zhou
Debjyoti Kundu
Jonathan Robles-Linares
Vik Meadows
Keisaku Sato
Leonardo Baiocchi
Burcin Ekser
Shannon Glaser
Gianfranco Alpini
Heather Francis
Lindsey Kennedy
Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
Cells
cholangiocytes
bile acids
cholestatic liver disease
ductular reaction
non-alcoholic fatty liver disease
author_facet Tianhao Zhou
Debjyoti Kundu
Jonathan Robles-Linares
Vik Meadows
Keisaku Sato
Leonardo Baiocchi
Burcin Ekser
Shannon Glaser
Gianfranco Alpini
Heather Francis
Lindsey Kennedy
author_sort Tianhao Zhou
title Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
title_short Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
title_full Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
title_fullStr Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
title_sort feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-08-01
description Fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the United States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; however, the impact of other biliary epithelial cells (i.e., cholangiocytes) in the promotion of NAFLD is growing. This review article will discuss how cholestatic injury and cholangiocyte activity/ductular reaction influence NAFLD progression. Furthermore, this review will provide informative details regarding the fundamental properties of cholangiocytes and bile acid signaling that can influence NAFLD. Lastly, studies relating to the pathogenesis of NAFLD, cholangiopathies, and ductular reaction will be analyzed to help gain insight for potential therapies.
topic cholangiocytes
bile acids
cholestatic liver disease
ductular reaction
non-alcoholic fatty liver disease
url https://www.mdpi.com/2073-4409/10/8/2072
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