The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study
Objective: This study aimed to investigate the associations between previous TORCH infection (cytomegalovirus, toxoplasmosis, herpes simplex virus, and rubella) with pregnancy and neonatal outcomes in couples undergoing IVF/ICSI-ET.Materials and Methods: A total of 18,074 couples underwent fresh IVF...
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Frontiers Media S.A.
2020-08-01
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Series: | Frontiers in Endocrinology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00466/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yifeng Liu Yiqing Wu Feixia Wang Siwen Wang Wei Zhao Lifen Chen Shijiong Tu Yuli Qian Yun Liao Yun Huang Runjv Zhang Runjv Zhang Gufeng Xu Gufeng Xu Dan Zhang Dan Zhang |
spellingShingle |
Yifeng Liu Yiqing Wu Feixia Wang Siwen Wang Wei Zhao Lifen Chen Shijiong Tu Yuli Qian Yun Liao Yun Huang Runjv Zhang Runjv Zhang Gufeng Xu Gufeng Xu Dan Zhang Dan Zhang The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study Frontiers in Endocrinology TORCH previous infection pregnancy outcome neonatal outcome IVF/ICSI-ET |
author_facet |
Yifeng Liu Yiqing Wu Feixia Wang Siwen Wang Wei Zhao Lifen Chen Shijiong Tu Yuli Qian Yun Liao Yun Huang Runjv Zhang Runjv Zhang Gufeng Xu Gufeng Xu Dan Zhang Dan Zhang |
author_sort |
Yifeng Liu |
title |
The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study |
title_short |
The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study |
title_full |
The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study |
title_fullStr |
The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study |
title_full_unstemmed |
The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort Study |
title_sort |
association between previous torch infections and pregnancy and neonatal outcomes in ivf/icsi-et: a retrospective cohort study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-08-01 |
description |
Objective: This study aimed to investigate the associations between previous TORCH infection (cytomegalovirus, toxoplasmosis, herpes simplex virus, and rubella) with pregnancy and neonatal outcomes in couples undergoing IVF/ICSI-ET.Materials and Methods: A total of 18,074 couples underwent fresh IVF/ICSI-ET (in vitro fertilization/intracytoplasmic sperm injection–embryo transfer) cycles were included in our analyses. TORCH infection status was determined by serological confirmation of cytomegalovirus, toxoplasmosis, herpes simplex virus, and rubella IgG in the absence of IgM antibodies. Clinical pregnancy, ectopic pregnancy, miscarriage, live birth, preterm birth, congenital malformation, and perinatal death were evaluated in both infection and non-infection group. Multivariate logistic regression was applied to calculate odds ratio.Results: Previous toxoplasmosis infection is associated with a significantly decreased preterm birth rate [P = 0.045, OR = 0.755 (95% CI, 0.571–0.997), Adjusted OR = 0.749 (95%CI, 0.566–0.991)]. No differences in clinical pregnancy, ectopic pregnancy, miscarriage, and perinatal death were observed between the corresponding TORCH infection group [IgM (–) IgG(+)] and the non-infection group [IgM (–) IgG (–)].Conclusions: Previous TORCH infections were not associated with adverse pregnancy and neonatal outcomes in IVF/ICSI-ET overall, and toxoplasmosis infection might be associated with a lower preterm birth rate in patients underwent IVF/ICSI-ET. The necessity of TORCH IgG screening in IVF procedure might need re-evaluation, and further cost-effective analysis might be helpful for the clinical management strategy. |
topic |
TORCH previous infection pregnancy outcome neonatal outcome IVF/ICSI-ET |
url |
https://www.frontiersin.org/article/10.3389/fendo.2020.00466/full |
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doaj-2b749cac8e184ea7a16a5347db5bfddd2020-11-25T03:23:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-08-011110.3389/fendo.2020.00466509621The Association Between Previous TORCH Infections and Pregnancy and Neonatal Outcomes in IVF/ICSI-ET: A Retrospective Cohort StudyYifeng Liu0Yiqing Wu1Feixia Wang2Siwen Wang3Wei Zhao4Lifen Chen5Shijiong Tu6Yuli Qian7Yun Liao8Yun Huang9Runjv Zhang10Runjv Zhang11Gufeng Xu12Gufeng Xu13Dan Zhang14Dan Zhang15Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaWomen's Reproductive Health Research Key Laboratory of Zhejiang Province, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaWomen's Reproductive Health Research Key Laboratory of Zhejiang Province, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United StatesKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesKey Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, ChinaWomen's Reproductive Health Research Key Laboratory of Zhejiang Province, Hangzhou, ChinaObjective: This study aimed to investigate the associations between previous TORCH infection (cytomegalovirus, toxoplasmosis, herpes simplex virus, and rubella) with pregnancy and neonatal outcomes in couples undergoing IVF/ICSI-ET.Materials and Methods: A total of 18,074 couples underwent fresh IVF/ICSI-ET (in vitro fertilization/intracytoplasmic sperm injection–embryo transfer) cycles were included in our analyses. TORCH infection status was determined by serological confirmation of cytomegalovirus, toxoplasmosis, herpes simplex virus, and rubella IgG in the absence of IgM antibodies. Clinical pregnancy, ectopic pregnancy, miscarriage, live birth, preterm birth, congenital malformation, and perinatal death were evaluated in both infection and non-infection group. Multivariate logistic regression was applied to calculate odds ratio.Results: Previous toxoplasmosis infection is associated with a significantly decreased preterm birth rate [P = 0.045, OR = 0.755 (95% CI, 0.571–0.997), Adjusted OR = 0.749 (95%CI, 0.566–0.991)]. No differences in clinical pregnancy, ectopic pregnancy, miscarriage, and perinatal death were observed between the corresponding TORCH infection group [IgM (–) IgG(+)] and the non-infection group [IgM (–) IgG (–)].Conclusions: Previous TORCH infections were not associated with adverse pregnancy and neonatal outcomes in IVF/ICSI-ET overall, and toxoplasmosis infection might be associated with a lower preterm birth rate in patients underwent IVF/ICSI-ET. The necessity of TORCH IgG screening in IVF procedure might need re-evaluation, and further cost-effective analysis might be helpful for the clinical management strategy.https://www.frontiersin.org/article/10.3389/fendo.2020.00466/fullTORCHprevious infectionpregnancy outcomeneonatal outcomeIVF/ICSI-ET |