The lighthouse at the end of the chromosome* [version 1; referees: 3 approved]
Fluorescence microscopy can be used to assess the dynamic localization and intensity of single entities in vitro or in living cells. It has been applied with aplomb to many different cellular processes and has significantly enlightened our understanding of the heterogeneity and complexity of biologi...
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doaj-2b79a7b1899a4044a91770fc13b338482020-11-25T02:54:40ZengF1000 Research LtdF1000Research2046-14022015-12-01410.12688/f1000research.6664.17160The lighthouse at the end of the chromosome* [version 1; referees: 3 approved]Yahya Benslimane0Lea Harrington1Department of Molecular Biology, University of Montreal, Institute for Research in Immunology and Cancer, Montreal, Quebec, CanadaDepartment of Medicine, University of Montreal, Institute for Research in Immunology and Cancer, Montreal, Quebec, CanadaFluorescence microscopy can be used to assess the dynamic localization and intensity of single entities in vitro or in living cells. It has been applied with aplomb to many different cellular processes and has significantly enlightened our understanding of the heterogeneity and complexity of biological systems. Recently, high-resolution fluorescence microscopy has been brought to bear on telomeres, leading to new insights into telomere spatial organization and accessibility, and into the mechanistic nuances of telomere elongation. We provide a snapshot of some of these recent advances with a focus on mammalian systems, and show how three-dimensional, time-lapse microscopy and single-molecule fluorescence shine a new light on the end of the chromosome.http://f1000research.com/articles/4-1427/v1Experimental Biophysical MethodsNuclear Structure & FunctionProtein FoldingStructure: Transcription & Translation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yahya Benslimane Lea Harrington |
spellingShingle |
Yahya Benslimane Lea Harrington The lighthouse at the end of the chromosome* [version 1; referees: 3 approved] F1000Research Experimental Biophysical Methods Nuclear Structure & Function Protein Folding Structure: Transcription & Translation |
author_facet |
Yahya Benslimane Lea Harrington |
author_sort |
Yahya Benslimane |
title |
The lighthouse at the end of the chromosome* [version 1; referees: 3 approved] |
title_short |
The lighthouse at the end of the chromosome* [version 1; referees: 3 approved] |
title_full |
The lighthouse at the end of the chromosome* [version 1; referees: 3 approved] |
title_fullStr |
The lighthouse at the end of the chromosome* [version 1; referees: 3 approved] |
title_full_unstemmed |
The lighthouse at the end of the chromosome* [version 1; referees: 3 approved] |
title_sort |
lighthouse at the end of the chromosome* [version 1; referees: 3 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2015-12-01 |
description |
Fluorescence microscopy can be used to assess the dynamic localization and intensity of single entities in vitro or in living cells. It has been applied with aplomb to many different cellular processes and has significantly enlightened our understanding of the heterogeneity and complexity of biological systems. Recently, high-resolution fluorescence microscopy has been brought to bear on telomeres, leading to new insights into telomere spatial organization and accessibility, and into the mechanistic nuances of telomere elongation. We provide a snapshot of some of these recent advances with a focus on mammalian systems, and show how three-dimensional, time-lapse microscopy and single-molecule fluorescence shine a new light on the end of the chromosome. |
topic |
Experimental Biophysical Methods Nuclear Structure & Function Protein Folding Structure: Transcription & Translation |
url |
http://f1000research.com/articles/4-1427/v1 |
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