Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages
Rhesus macaques can be readily infected with chimeric simian-human immunodeficiency viruses (SHIV) as a suitable virus challenge system for testing the efficacy of HIV vaccines. Three Chinese-origin rhesus macaques (ChRM) were inoculated intravenously (IV) with SHIVC109P4 in a rapid serial in vivo p...
Main Authors: | Gerald K. Chege, Craig H. Adams, Alana T. Keyser, Valerie Bekker, Lynn Morris, Francois J. Villinger, Anna-Lise Williamson, Rosamund E. Chapman |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
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Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/13/3/397 |
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