Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer
Worldwide, especially in China, lung cancer accounts to a major cause of mortality related to cancer. Treatment decisions mainly depend on oncogenic driver mutations, which offer novel therapeutic targets for anticancer therapy. However, studies of genomic profiling of driver gene mutations in mainl...
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doaj-2b822cede1094337a23a7192c13748b02020-11-25T01:39:51ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-10-011010.3389/fgene.2019.01008446982Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung CancerHongxue Meng0Xuejie Guo1Dawei Sun2Yuebin Liang3Jidong Lang4Yingmin Han5Qingqing Lu6Yanxiang Zhang7Yanxin An8Geng Tian9Dawei Yuan10Shidong Xu11Jingshu Geng12Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Medicine, Geneis (Beijing) Co., Ltd., Beijing, ChinaDepartment of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Pathology, Harbin Medical University Cancer Hospital, Harbin, ChinaWorldwide, especially in China, lung cancer accounts to a major cause of mortality related to cancer. Treatment decisions mainly depend on oncogenic driver mutations, which offer novel therapeutic targets for anticancer therapy. However, studies of genomic profiling of driver gene mutations in mainland China are rare. Hence, this is an extensive study of these mutations in Non-small-cell lung cancer (NSCLC) Chinese patients. Comparison of driver gene mutations of lung adenocarcinoma with other races showed that the mutational frequencies were similar within the different East Asian populations, while there were differences between East Asian and non-Asian populations. Further, four promising candidates for druggable mutations of epidermal growth factor receptor (EGFR) were revealed that open up avenues to develop and design personal therapeutic approaches for patients harboring mutations. These results will help to develop personalized therapy targeting NSCLC.https://www.frontiersin.org/article/10.3389/fgene.2019.01008/fulllung cancerdriver mutationsepidemiologyEGFRpersonalized medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongxue Meng Xuejie Guo Dawei Sun Yuebin Liang Jidong Lang Yingmin Han Qingqing Lu Yanxiang Zhang Yanxin An Geng Tian Dawei Yuan Shidong Xu Jingshu Geng |
spellingShingle |
Hongxue Meng Xuejie Guo Dawei Sun Yuebin Liang Jidong Lang Yingmin Han Qingqing Lu Yanxiang Zhang Yanxin An Geng Tian Dawei Yuan Shidong Xu Jingshu Geng Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer Frontiers in Genetics lung cancer driver mutations epidemiology EGFR personalized medicine |
author_facet |
Hongxue Meng Xuejie Guo Dawei Sun Yuebin Liang Jidong Lang Yingmin Han Qingqing Lu Yanxiang Zhang Yanxin An Geng Tian Dawei Yuan Shidong Xu Jingshu Geng |
author_sort |
Hongxue Meng |
title |
Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer |
title_short |
Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer |
title_full |
Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer |
title_fullStr |
Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer |
title_full_unstemmed |
Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer |
title_sort |
genomic profiling of driver gene mutations in chinese patients with non-small cell lung cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2019-10-01 |
description |
Worldwide, especially in China, lung cancer accounts to a major cause of mortality related to cancer. Treatment decisions mainly depend on oncogenic driver mutations, which offer novel therapeutic targets for anticancer therapy. However, studies of genomic profiling of driver gene mutations in mainland China are rare. Hence, this is an extensive study of these mutations in Non-small-cell lung cancer (NSCLC) Chinese patients. Comparison of driver gene mutations of lung adenocarcinoma with other races showed that the mutational frequencies were similar within the different East Asian populations, while there were differences between East Asian and non-Asian populations. Further, four promising candidates for druggable mutations of epidermal growth factor receptor (EGFR) were revealed that open up avenues to develop and design personal therapeutic approaches for patients harboring mutations. These results will help to develop personalized therapy targeting NSCLC. |
topic |
lung cancer driver mutations epidemiology EGFR personalized medicine |
url |
https://www.frontiersin.org/article/10.3389/fgene.2019.01008/full |
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