Comparative Response of the Hepatic Transcriptomes of Domesticated and Wild Turkey to Aflatoxin B1

Comparative Response of the Hepatic Transcriptomes of Domesticated and Wild Turkey to Aflatoxin B1

The food-borne mycotoxin aflatoxin B1 (AFB1) poses a significant risk to poultry, which are highly susceptible to its hepatotoxic effects. Domesticated turkeys (Meleagris gallopavo) are especially sensitive, whereas wild turkeys (M. g. silvestris) are more resistant. AFB1 toxicity entails bioactivat...

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Bibliographic Details
Main Authors: Kent M. Reed, Kristelle M. Mendoza, Juan E. Abrahante, Roger A. Coulombe
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Toxins
Subjects:
aflatoxin B1
domesticated turkey
wild turkey
liver
RNA-seq
differential expression
Key Contribution
Results of this study support the hypothesis that the greater ability of wild turkeys to detoxify AFB1 is related to higher constitutive expression of GSTA3 coupled with an inherited (genetic) difference in functional expression in domesticated birds. Key differences in GSTA3 expression between the Eastern wild and domesticated turkeys is not unique to these genetic lines but is a broader phenomenon indicating lower fitness in domesticated birds. Results of RNA-seq analysis emphasize the differential response of these genetically distinct birds, demonstrating significant differences in expression of Phase I and Phase II genes and in genes important in toxic response.
Online Access:http://www.mdpi.com/2072-6651/10/1/42

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