The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future
Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been impl...
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doaj-2b8e9cd6989a41ff9999edfd5e3a54a12021-09-25T23:49:26ZengMDPI AGCancers2072-66942021-09-01134576457610.3390/cancers13184576The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and FutureHung-Yu Lin0Hui-Wen Ho1Yen-Hsiang Chang2Chun-Jui Wei3Pei-Yi Chu4Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, TaiwanResearch Assistant Center, Show Chwan Memorial Hospital, Changhua 500, TaiwanDepartment of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pathology, Show Chwan Memorial Hospital, Changhua 500, TaiwanGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, TaiwanBreast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.https://www.mdpi.com/2072-6694/13/18/4576breast cancertherapyferroptosisiron metabolismlipid peroxidationantioxidant defense |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hung-Yu Lin Hui-Wen Ho Yen-Hsiang Chang Chun-Jui Wei Pei-Yi Chu |
spellingShingle |
Hung-Yu Lin Hui-Wen Ho Yen-Hsiang Chang Chun-Jui Wei Pei-Yi Chu The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future Cancers breast cancer therapy ferroptosis iron metabolism lipid peroxidation antioxidant defense |
author_facet |
Hung-Yu Lin Hui-Wen Ho Yen-Hsiang Chang Chun-Jui Wei Pei-Yi Chu |
author_sort |
Hung-Yu Lin |
title |
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future |
title_short |
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future |
title_full |
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future |
title_fullStr |
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future |
title_full_unstemmed |
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future |
title_sort |
evolving role of ferroptosis in breast cancer: translational implications present and future |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-09-01 |
description |
Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC. |
topic |
breast cancer therapy ferroptosis iron metabolism lipid peroxidation antioxidant defense |
url |
https://www.mdpi.com/2072-6694/13/18/4576 |
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