In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration
For years, in order to improve bone regeneration and prevent the need of a second stage surgery to remove non-resorbable membranes, biological absorbable membranes have gradually been developed and applied in guided tissue regeneration (GTR). The present study’s main objective was to achieve space m...
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doaj-2b8f8ad0003a403385eb804fff714b2c2020-11-24T22:43:10ZengMDPI AGMaterials1996-19442016-11-0191194910.3390/ma9110949ma9110949In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone RegenerationEisner Salamanca0Chi-Yang Tsai1Yu-Hwa Pan2Yu-Te Lin3Haw-Ming Huang4Nai-Chia Teng5Che-Tong Lin6Sheng-Wei Feng7Wei-Jen Chang8School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSunmax Biotech Co., Ltd., Tainan 741, TaiwanGraduate Institute of Biomedical Materials & Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanFor years, in order to improve bone regeneration and prevent the need of a second stage surgery to remove non-resorbable membranes, biological absorbable membranes have gradually been developed and applied in guided tissue regeneration (GTR). The present study’s main objective was to achieve space maintenance and bone regeneration using a new freeze-dried developed porcine collagen membrane, and compare it with an already commercial collagen membrane, when both were used with a bovine xenograft in prepared alveolar ridge bone defects. Prior to surgery, the membrane’s vitality analysis showed statistically significant higher cell proliferation in the test membrane over the commercial one. In six beagle dogs, commercial bone xenograft was packed in lateral ridge bone defects prepared in the left and right side and then covered with test porcine collagen membrane or commercial collagen membrane. Alveolar height changes were measured. Histomorphometric results, in vitro and in vivo properties indicated that the new porcine collagen membrane is biocompatible, enhances bone xenograft osteoconduction, and reduces the alveolar ridge height reabsorption rate.http://www.mdpi.com/1996-1944/9/11/949collagen membranealveolar boneguided bone regenerationanimal study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eisner Salamanca Chi-Yang Tsai Yu-Hwa Pan Yu-Te Lin Haw-Ming Huang Nai-Chia Teng Che-Tong Lin Sheng-Wei Feng Wei-Jen Chang |
spellingShingle |
Eisner Salamanca Chi-Yang Tsai Yu-Hwa Pan Yu-Te Lin Haw-Ming Huang Nai-Chia Teng Che-Tong Lin Sheng-Wei Feng Wei-Jen Chang In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration Materials collagen membrane alveolar bone guided bone regeneration animal study |
author_facet |
Eisner Salamanca Chi-Yang Tsai Yu-Hwa Pan Yu-Te Lin Haw-Ming Huang Nai-Chia Teng Che-Tong Lin Sheng-Wei Feng Wei-Jen Chang |
author_sort |
Eisner Salamanca |
title |
In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration |
title_short |
In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration |
title_full |
In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration |
title_fullStr |
In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration |
title_full_unstemmed |
In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration |
title_sort |
in vitro and in vivo study of a novel porcine collagen membrane for guided bone regeneration |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2016-11-01 |
description |
For years, in order to improve bone regeneration and prevent the need of a second stage surgery to remove non-resorbable membranes, biological absorbable membranes have gradually been developed and applied in guided tissue regeneration (GTR). The present study’s main objective was to achieve space maintenance and bone regeneration using a new freeze-dried developed porcine collagen membrane, and compare it with an already commercial collagen membrane, when both were used with a bovine xenograft in prepared alveolar ridge bone defects. Prior to surgery, the membrane’s vitality analysis showed statistically significant higher cell proliferation in the test membrane over the commercial one. In six beagle dogs, commercial bone xenograft was packed in lateral ridge bone defects prepared in the left and right side and then covered with test porcine collagen membrane or commercial collagen membrane. Alveolar height changes were measured. Histomorphometric results, in vitro and in vivo properties indicated that the new porcine collagen membrane is biocompatible, enhances bone xenograft osteoconduction, and reduces the alveolar ridge height reabsorption rate. |
topic |
collagen membrane alveolar bone guided bone regeneration animal study |
url |
http://www.mdpi.com/1996-1944/9/11/949 |
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