No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes
Maternal metabolism and intrauterine conditions influence development of health and disease in offspring, leading to metabolic, physiologic, and/or epigenetic adaptation of the fetus. Maternal gestational diabetes (GDM) leads to higher incidence of obesity and type 2 diabetes in offspring. We have p...
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doaj-2bb72073dac44a3fb715a5c0860a3d962021-02-09T00:02:53ZengMDPI AGNutrients2072-66432021-02-011355655610.3390/nu13020556No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational DiabetesFranziska Schleger0Katarzyna Linder1Louise Fritsche2Jan Pauluschke-Fröhlich3Martin Heni4Magdalene Weiss5Hans-Ulrich Häring6Hubert Preissl7Andreas Fritsche8Helmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyHelmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyHelmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyDepartment of Obstetrics and Gynecology, University Hospital Tübingen, 72076 Tübingen, GermanyHelmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyDepartment of Obstetrics and Gynecology, University Hospital Tübingen, 72076 Tübingen, GermanyHelmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyHelmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyHelmholtz Center Munich at the University of Tübingen/fMEG Center, Institute for Diabetes Research and Metabolic Diseases, 72076 Tübingen, GermanyMaternal metabolism and intrauterine conditions influence development of health and disease in offspring, leading to metabolic, physiologic, and/or epigenetic adaptation of the fetus. Maternal gestational diabetes (GDM) leads to higher incidence of obesity and type 2 diabetes in offspring. We have previously shown that fetuses of insulin-resistant mothers with GDM have a delayed reaction to auditory stimuli in the postprandial state, indicating a fetal central insulin resistance. We tested whether this effect could be influenced by a lifestyle intervention in mothers with GDM, including diet counselling and regular blood glucose measurements. We measured fetal brain activity over the course of a maternal glucose challenge, at two measurement time points (baseline at an average of 29 weeks of gestation and follow-up after 4 weeks) in mothers with GDM and mothers with normal glucose tolerance (NGT). Data from eight mothers were able to be included. Fetuses of GDM mothers showed longer latencies than those of NGT mothers postprandially at both measurement time points during the third trimester and did not show a difference in response patterns between baseline and after 4 weeks. Maternal postprandial blood glucose and insulin values did not change from baseline to follow-up either. While the overall intervention seems to have been effective, it does not appear to have influenced the fetal postprandial brain responses. This might have been because interventions for GDM take place relatively late in pregnancy. Future research should focus on maternal lifestyle interventions as early as possible during gestation, or even prenatally.https://www.mdpi.com/2072-6643/13/2/556fetal MEGoGTTtype 2 diabetesmaternal metabolismfetal programming |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Franziska Schleger Katarzyna Linder Louise Fritsche Jan Pauluschke-Fröhlich Martin Heni Magdalene Weiss Hans-Ulrich Häring Hubert Preissl Andreas Fritsche |
spellingShingle |
Franziska Schleger Katarzyna Linder Louise Fritsche Jan Pauluschke-Fröhlich Martin Heni Magdalene Weiss Hans-Ulrich Häring Hubert Preissl Andreas Fritsche No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes Nutrients fetal MEG oGTT type 2 diabetes maternal metabolism fetal programming |
author_facet |
Franziska Schleger Katarzyna Linder Louise Fritsche Jan Pauluschke-Fröhlich Martin Heni Magdalene Weiss Hans-Ulrich Häring Hubert Preissl Andreas Fritsche |
author_sort |
Franziska Schleger |
title |
No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes |
title_short |
No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes |
title_full |
No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes |
title_fullStr |
No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes |
title_full_unstemmed |
No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes |
title_sort |
no effect of lifestyle intervention during third trimester on brain programming in fetuses of mothers with gestational diabetes |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-02-01 |
description |
Maternal metabolism and intrauterine conditions influence development of health and disease in offspring, leading to metabolic, physiologic, and/or epigenetic adaptation of the fetus. Maternal gestational diabetes (GDM) leads to higher incidence of obesity and type 2 diabetes in offspring. We have previously shown that fetuses of insulin-resistant mothers with GDM have a delayed reaction to auditory stimuli in the postprandial state, indicating a fetal central insulin resistance. We tested whether this effect could be influenced by a lifestyle intervention in mothers with GDM, including diet counselling and regular blood glucose measurements. We measured fetal brain activity over the course of a maternal glucose challenge, at two measurement time points (baseline at an average of 29 weeks of gestation and follow-up after 4 weeks) in mothers with GDM and mothers with normal glucose tolerance (NGT). Data from eight mothers were able to be included. Fetuses of GDM mothers showed longer latencies than those of NGT mothers postprandially at both measurement time points during the third trimester and did not show a difference in response patterns between baseline and after 4 weeks. Maternal postprandial blood glucose and insulin values did not change from baseline to follow-up either. While the overall intervention seems to have been effective, it does not appear to have influenced the fetal postprandial brain responses. This might have been because interventions for GDM take place relatively late in pregnancy. Future research should focus on maternal lifestyle interventions as early as possible during gestation, or even prenatally. |
topic |
fetal MEG oGTT type 2 diabetes maternal metabolism fetal programming |
url |
https://www.mdpi.com/2072-6643/13/2/556 |
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