The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

The precise assembly of inner ear hair cell stereocilia into rows of increasing height is critical for mechanotransduction and the sense of hearing. Yet, how the lengths of actin-based stereocilia are regulated remains poorly understood. Mutations of the molecular motor myosin 15 stunt stereocilia g...

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Bibliographic Details
Main Authors: Qing Fang, Artur A Indzhykulian, Mirna Mustapha, Gavin P Riordan, David F Dolan, Thomas B Friedman, Inna A Belyantseva, Gregory I Frolenkov, Sally A Camper, Jonathan E Bird
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
deafness
stereocilia
myosin
actin
inner ear
hearing
Online Access:https://elifesciences.org/articles/08627

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