CAR-T cells and BiTEs in solid tumors: challenges and perspectives

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Abstract Chimeric antigen receptor (CAR)-modified T cells and BiTEs are both immunotherapies which redirect T cell specificity against a tumor-specific antigen through the use of antibody fragments. They demonstrated remarkable efficacy in B cell hematologic malignancies, thus paving the way for the...

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Bibliographic Details
Main Authors: Julien Edeline, Roch Houot, Aurélien Marabelle, Marion Alcantara
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Hematology & Oncology
Subjects:
CAR-T cells
BiTEs
Bispecific antibodies
Solid tumors
Online Access:https://doi.org/10.1186/s13045-021-01067-5

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