The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity
The phytochemical analysis of the polar extracts of Cedrus brevifolia needles yielded 20 compounds, namely from the methanol extract we isolated three flavonoids (1–3), one hydrolysable tannin (4), eleven phenolic derivatives (5–15) and one apocarotenoid (16), while from the methanol: water (5:1) ex...
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doaj-2bbccdfd374442aeaeeb6cdcdbfe64de2020-11-25T00:17:33ZengMDPI AGPlants2223-77472017-12-0171110.3390/plants7010001plants7010001The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant ActivityAndreas Douros0Dimitra Hadjipavlou-Litina1Konstantinos Nikolaou2Helen Skaltsa3Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, GreeceDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Forests, Ministry of Agriculture, Natural Resources and Environment, Nicosia 1414, CyprusDepartment of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, GreeceThe phytochemical analysis of the polar extracts of Cedrus brevifolia needles yielded 20 compounds, namely from the methanol extract we isolated three flavonoids (1–3), one hydrolysable tannin (4), eleven phenolic derivatives (5–15) and one apocarotenoid (16), while from the methanol: water (5:1) extract we isolated four flavonoids (17–20). Chemical structures of all isolated compounds were determined by 1D, 2D-NMR (1 Dimension, 2 Dimensions Nuclear Magnetic Resonance) and UV-Vis (Ultraviolet-Visible) spectroscopy. Furthermore, the antioxidant potentials and the anti-inflammatory activities of both crude extracts and isolates were evaluated through DPPH radical scavenging capability, linoleic acid lipid peroxidation inhibition, and soybean LOX inhibition assays. This is the first report on the chemical profile of C. brevifolia needles. Catechin was the main compound derived from the methanol extract. According to our results, 4-O-β-d-glucopyranyl trans-p-coumaric acid and taxifolin were the most active ingredients.https://www.mdpi.com/2223-7747/7/1/1C. brevifoliaflavonoidscatechinsimple phenolsapocarotenoidsbioactivity, antioxidantreducing powertotal antioxidant capacityreactive oxygen species |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreas Douros Dimitra Hadjipavlou-Litina Konstantinos Nikolaou Helen Skaltsa |
spellingShingle |
Andreas Douros Dimitra Hadjipavlou-Litina Konstantinos Nikolaou Helen Skaltsa The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity Plants C. brevifolia flavonoids catechin simple phenols apocarotenoids bioactivity, antioxidant reducing power total antioxidant capacity reactive oxygen species |
author_facet |
Andreas Douros Dimitra Hadjipavlou-Litina Konstantinos Nikolaou Helen Skaltsa |
author_sort |
Andreas Douros |
title |
The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity |
title_short |
The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity |
title_full |
The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity |
title_fullStr |
The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity |
title_full_unstemmed |
The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity |
title_sort |
occurrence of flavonoids and related compounds in cedrus brevifolia a. henry ex elwes & a. henry needles. inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity |
publisher |
MDPI AG |
series |
Plants |
issn |
2223-7747 |
publishDate |
2017-12-01 |
description |
The phytochemical analysis of the polar extracts of Cedrus brevifolia needles yielded 20 compounds, namely from the methanol extract we isolated three flavonoids (1–3), one hydrolysable tannin (4), eleven phenolic derivatives (5–15) and one apocarotenoid (16), while from the methanol: water (5:1) extract we isolated four flavonoids (17–20). Chemical structures of all isolated compounds were determined by 1D, 2D-NMR (1 Dimension, 2 Dimensions Nuclear Magnetic Resonance) and UV-Vis (Ultraviolet-Visible) spectroscopy. Furthermore, the antioxidant potentials and the anti-inflammatory activities of both crude extracts and isolates were evaluated through DPPH radical scavenging capability, linoleic acid lipid peroxidation inhibition, and soybean LOX inhibition assays. This is the first report on the chemical profile of C. brevifolia needles. Catechin was the main compound derived from the methanol extract. According to our results, 4-O-β-d-glucopyranyl trans-p-coumaric acid and taxifolin were the most active ingredients. |
topic |
C. brevifolia flavonoids catechin simple phenols apocarotenoids bioactivity, antioxidant reducing power total antioxidant capacity reactive oxygen species |
url |
https://www.mdpi.com/2223-7747/7/1/1 |
work_keys_str_mv |
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