Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators

Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators

Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which...

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Bibliographic Details
Main Authors: Sanjita Paudel, Aarajana Shrestha, Piljoung Cho, Riya Shrestha, Younah Kim, Taeho Lee, Ju-Hyun Kim, Tae Cheon Jeong, Eung-Seok Lee, Sangkyu Lee
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
Loxoprofen
drug-drug interaction
CYP3A
Dexamethasone
Ketoconazole
Online Access:https://www.mdpi.com/1999-4923/11/9/479

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