Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion
Introduction: It is well established that overt hypothyroidism, itself was a risk factor for atherosclerosis. Retinal Venous Occlusion (RVO) is caused by localised atherosclerosis. Subclinical Hypothyroidism (SCH) also cause arteriosclerosis thereby could be an important causative factor for RVO...
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doaj-2bd0aa818ac24d1aaf4ee3ce4a5fc2162021-06-14T04:24:01ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-04-01154BC08BC1010.7860/JCDR/2021/47113.14793Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein OcclusionAMIT KUMAR GUPTA0KAPIL DEB LAHIRI1Assistant Professor, Department of Ophthalmology, IPGME and R-SSKM Hospital, Kolkata, West Bengal, India.Assistant Professor, Department of Biochemistry, IPGME and R-SSKM Hospital, Kolkata, West Bengal, India.Introduction: It is well established that overt hypothyroidism, itself was a risk factor for atherosclerosis. Retinal Venous Occlusion (RVO) is caused by localised atherosclerosis. Subclinical Hypothyroidism (SCH) also cause arteriosclerosis thereby could be an important causative factor for RVO. But no study on SCH in RVO has taken place in Indian population. Aim: To find the prevalence of SCH in RVO in Indian Population. Materials and Methods: Thyroid hormones and Anti-Tissue Peroxidise (TPO) antibody was measured in 479 RVO cases in this two year prospective cross-sectional study in ESIC medical college. Data was entered into Microsoft Excel and presented in tables. Results: In this study, 312 males (aged 52±7.2 years) and 167 females (aged 47±7.7 years) with RVO were screened for thyroid hormones and anti-TPO antibody. Thyroid disorders were found in 162 patients out of 479 participants in this study (33.8%). Moreover, 52 cases were found to have SCH (10.8%) which is 32.1% of total thyroid disorder among RVO cases. Total of 118 patients had high anti-TPO antibody among 162 RVO cases with thyroid disorders (72.8%) and only 67 had high anti-TPO antibody among 317 euthyroid RVO cases (21.1%). Conclusion: This study has shown that SCH was a modifiable risk factor of RVO. Therefore, understanding the prevalence of SCH in this population might help in the prevention of RVO by secondary preventive intervention. Moreover, all SCH cases should be referred to ophthalmologist for evaluation of retinal vasculature.https://www.jcdr.net/articles/PDF/14793/47113_CE[Ra1]_F[SK]_PF1(MG_SL)_PFA(MG_KM)_PN(KM).pdfretinal venous occlusionsubclinical hypothyroidismthyroid peroxidase antibody |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
AMIT KUMAR GUPTA KAPIL DEB LAHIRI |
spellingShingle |
AMIT KUMAR GUPTA KAPIL DEB LAHIRI Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion Journal of Clinical and Diagnostic Research retinal venous occlusion subclinical hypothyroidism thyroid peroxidase antibody |
author_facet |
AMIT KUMAR GUPTA KAPIL DEB LAHIRI |
author_sort |
AMIT KUMAR GUPTA |
title |
Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion |
title_short |
Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion |
title_full |
Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion |
title_fullStr |
Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion |
title_full_unstemmed |
Subclinical Hypothyroidism: A Modifiable Risk Factor for Retinal Vein Occlusion |
title_sort |
subclinical hypothyroidism: a modifiable risk factor for retinal vein occlusion |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2021-04-01 |
description |
Introduction: It is well established that overt hypothyroidism, itself
was a risk factor for atherosclerosis. Retinal Venous Occlusion (RVO)
is caused by localised atherosclerosis. Subclinical Hypothyroidism
(SCH) also cause arteriosclerosis thereby could be an important
causative factor for RVO. But no study on SCH in RVO has taken
place in Indian population.
Aim: To find the prevalence of SCH in RVO in Indian Population.
Materials and Methods: Thyroid hormones and Anti-Tissue
Peroxidise (TPO) antibody was measured in 479 RVO cases in
this two year prospective cross-sectional study in ESIC medical
college. Data was entered into Microsoft Excel and presented
in tables.
Results: In this study, 312 males (aged 52±7.2 years) and 167
females (aged 47±7.7 years) with RVO were screened for thyroid
hormones and anti-TPO antibody. Thyroid disorders were found
in 162 patients out of 479 participants in this study (33.8%).
Moreover, 52 cases were found to have SCH (10.8%) which is
32.1% of total thyroid disorder among RVO cases. Total of 118
patients had high anti-TPO antibody among 162 RVO cases
with thyroid disorders (72.8%) and only 67 had high anti-TPO
antibody among 317 euthyroid RVO cases (21.1%).
Conclusion: This study has shown that SCH was a modifiable risk
factor of RVO. Therefore, understanding the prevalence of SCH in
this population might help in the prevention of RVO by secondary
preventive intervention. Moreover, all SCH cases should be
referred to ophthalmologist for evaluation of retinal vasculature. |
topic |
retinal venous occlusion subclinical hypothyroidism thyroid peroxidase antibody |
url |
https://www.jcdr.net/articles/PDF/14793/47113_CE[Ra1]_F[SK]_PF1(MG_SL)_PFA(MG_KM)_PN(KM).pdf |
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AT amitkumargupta subclinicalhypothyroidismamodifiableriskfactorforretinalveinocclusion AT kapildeblahiri subclinicalhypothyroidismamodifiableriskfactorforretinalveinocclusion |
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