Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study
Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in gene...
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BMC
2021-06-01
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Series: | Lipids in Health and Disease |
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Online Access: | https://doi.org/10.1186/s12944-021-01482-0 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan Xia Chunyue Guo Kuo Liu Yunyi Xie Han Cao Wenjuan Peng Yanyan Sun Xiaohui Liu Bingxiao Li Ling Zhang |
spellingShingle |
Juan Xia Chunyue Guo Kuo Liu Yunyi Xie Han Cao Wenjuan Peng Yanyan Sun Xiaohui Liu Bingxiao Li Ling Zhang Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study Lipids in Health and Disease Lipoprotein (a) Cardiovascular risk Atrial fibrillation Arrhythmia Congestive heart failure Ischemic stroke |
author_facet |
Juan Xia Chunyue Guo Kuo Liu Yunyi Xie Han Cao Wenjuan Peng Yanyan Sun Xiaohui Liu Bingxiao Li Ling Zhang |
author_sort |
Juan Xia |
title |
Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study |
title_short |
Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study |
title_full |
Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study |
title_fullStr |
Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study |
title_full_unstemmed |
Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study |
title_sort |
association of lipoprotein (a) variants with risk of cardiovascular disease: a mendelian randomization study |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2021-06-01 |
description |
Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes. |
topic |
Lipoprotein (a) Cardiovascular risk Atrial fibrillation Arrhythmia Congestive heart failure Ischemic stroke |
url |
https://doi.org/10.1186/s12944-021-01482-0 |
work_keys_str_mv |
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doaj-2bd27c56f10648b39023b38620f19a5f2021-06-06T11:52:26ZengBMCLipids in Health and Disease1476-511X2021-06-0120111110.1186/s12944-021-01482-0Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization studyJuan Xia0Chunyue Guo1Kuo Liu2Yunyi Xie3Han Cao4Wenjuan Peng5Yanyan Sun6Xiaohui Liu7Bingxiao Li8Ling Zhang9Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University and Beijing Municipal Key Laboratory of Clinical EpidemiologyAbstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.https://doi.org/10.1186/s12944-021-01482-0Lipoprotein (a)Cardiovascular riskAtrial fibrillationArrhythmiaCongestive heart failureIschemic stroke |