Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types

Cell lines are used ubiquitously in cancer research but how well they represent the tumor type they were derived from is variable. Here, the authors compare transcriptomic profiles of 22 tumor types and cell lines and propose a new comprehensive cell line panel for pan-cancer studies.

Bibliographic Details
Main Authors: K. Yu, B. Chen, D. Aran, J. Charalel, C. Yau, D. M. Wolf, L. J. van ‘t Veer, A. J. Butte, T. Goldstein, M. Sirota
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11415-2
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spelling doaj-2bd5c7c643b4495ab1808a6fe07e85de2021-05-11T12:37:30ZengNature Publishing GroupNature Communications2041-17232019-08-0110111110.1038/s41467-019-11415-2Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor typesK. Yu0B. Chen1D. Aran2J. Charalel3C. Yau4D. M. Wolf5L. J. van ‘t Veer6A. J. Butte7T. Goldstein8M. Sirota9Bakar Computational Health Sciences Institute, University of California San FranciscoDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State UniversityBakar Computational Health Sciences Institute, University of California San FranciscoDepartment of Genetics, Stanford UniversityBuck Institute for Research on AgingDepartment of Surgery, University of California, San FranciscoDepartment of Laboratory Medicine, University of California, San FranciscoBakar Computational Health Sciences Institute, University of California San FranciscoBakar Computational Health Sciences Institute, University of California San FranciscoBakar Computational Health Sciences Institute, University of California San FranciscoCell lines are used ubiquitously in cancer research but how well they represent the tumor type they were derived from is variable. Here, the authors compare transcriptomic profiles of 22 tumor types and cell lines and propose a new comprehensive cell line panel for pan-cancer studies.https://doi.org/10.1038/s41467-019-11415-2
collection DOAJ
language English
format Article
sources DOAJ
author K. Yu
B. Chen
D. Aran
J. Charalel
C. Yau
D. M. Wolf
L. J. van ‘t Veer
A. J. Butte
T. Goldstein
M. Sirota
spellingShingle K. Yu
B. Chen
D. Aran
J. Charalel
C. Yau
D. M. Wolf
L. J. van ‘t Veer
A. J. Butte
T. Goldstein
M. Sirota
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
Nature Communications
author_facet K. Yu
B. Chen
D. Aran
J. Charalel
C. Yau
D. M. Wolf
L. J. van ‘t Veer
A. J. Butte
T. Goldstein
M. Sirota
author_sort K. Yu
title Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_short Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_full Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_fullStr Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_full_unstemmed Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_sort comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Cell lines are used ubiquitously in cancer research but how well they represent the tumor type they were derived from is variable. Here, the authors compare transcriptomic profiles of 22 tumor types and cell lines and propose a new comprehensive cell line panel for pan-cancer studies.
url https://doi.org/10.1038/s41467-019-11415-2
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