IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.
Insulin-like growth factor binding protein (IGFBP)-5 levels are increased in systemic sclerosis (SSc) skin and lung. We previously reported that IGFBP-5 is a pro-fibrotic factor that induces extracellular matrix (ECM) production and deposition. Since IGFBP-5 contains a nuclear localization signal (N...
Main Authors: | Yunyun Su, Tetsuya Nishimoto, Carol Feghali-Bostwick |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4478026?pdf=render |
Similar Items
-
IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators
by: Xinh-Xinh Nguyen, et al.
Published: (2018-10-01) -
The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
by: Hidekata Yasuoka, et al.
Published: (2014-01-01) -
Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5
by: Xinh-Xinh Nguyen, et al.
Published: (2021-12-01) -
How do the IGFBPs elicit their IGF-independent actions in breast epithelial cells
by: Burrows, Carla
Published: (2006) -
Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.
by: Sara M Garrett, et al.
Published: (2019-01-01)