Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP....

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Bibliographic Details
Main Authors: Hengyuan Liu, Tianyang Cao, Yun Xu, Yuanchen Dong, Dongsheng Liu
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
nucleic acid nanotechnology
DNA nanotechnology
DNA hydrogel
Online Access:http://www.mdpi.com/1422-0067/19/6/1633
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spelling doaj-2bdfc35b67514c7a9db9bd5350cb024b2020-11-25T00:51:50ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-05-01196163310.3390/ijms19061633ijms19061633Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP AptamerHengyuan Liu0Tianyang Cao1Yun Xu2Yuanchen Dong3Dongsheng Liu4Department of Chemistry, Tsinghua University, Beijing 100084, ChinaDepartment of Chemistry, Tsinghua University, Beijing 100084, ChinaCenter for Medical Device Evaluation, China Food and Drug Administration, Building 1, Qixiang Road, Beijing 100084, ChinaDepartment of Chemistry, Tsinghua University, Beijing 100084, ChinaDepartment of Chemistry, Tsinghua University, Beijing 100084, ChinaBy integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with the addition of the complementary sequence to the ATP aptamer, the mechanical strength could be increased to 570 Pa.http://www.mdpi.com/1422-0067/19/6/1633nucleic acid nanotechnologyDNA nanotechnologyDNA hydrogel
collection DOAJ
language English
format Article
sources DOAJ
author Hengyuan Liu
Tianyang Cao
Yun Xu
Yuanchen Dong
Dongsheng Liu
spellingShingle Hengyuan Liu
Tianyang Cao
Yun Xu
Yuanchen Dong
Dongsheng Liu
Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
International Journal of Molecular Sciences
nucleic acid nanotechnology
DNA nanotechnology
DNA hydrogel
author_facet Hengyuan Liu
Tianyang Cao
Yun Xu
Yuanchen Dong
Dongsheng Liu
author_sort Hengyuan Liu
title Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_short Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_full Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_fullStr Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_full_unstemmed Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_sort tuning the mechanical properties of a dna hydrogel in three phases based on atp aptamer
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2018-05-01
description By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with the addition of the complementary sequence to the ATP aptamer, the mechanical strength could be increased to 570 Pa.
topic nucleic acid nanotechnology
DNA nanotechnology
DNA hydrogel
url http://www.mdpi.com/1422-0067/19/6/1633
work_keys_str_mv AT hengyuanliu tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT tianyangcao tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT yunxu tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT yuanchendong tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT dongshengliu tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
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