The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery
Objective: The aim of the study was to assess the effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery. Design: A randomized prospective study. Setting: Cairo University, Egypt. Materials and Methods: The study included 150 patients undergoing aortic vascular surgery. I...
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Wolters Kluwer Medknow Publications
2016-01-01
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doaj-2bed07a1729c4c08b27c573195a206a62020-11-24T21:41:01ZengWolters Kluwer Medknow PublicationsAnnals of Cardiac Anaesthesia0971-97842016-01-0119460661310.4103/0971-9784.191570The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgeryRabie SolimanGomaa ZohryObjective: The aim of the study was to assess the effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery. Design: A randomized prospective study. Setting: Cairo University, Egypt. Materials and Methods: The study included 150 patients undergoing aortic vascular surgery. Intervention: The patients were classified into two groups (n = 75). Group D: The patients received a loading dose of 1 μg/kg dexmedetomidine over 15 min before induction and maintained as an infusion of 0.3 μg/kg/h to the end of the procedure. Group C: The patients received an equal volume of normal saline. The medication was prepared by the nursing staff and given to anesthetist blindly. Measurements: The monitors included the heart rate, mean arterial blood pressure, central venous pressure, electrocardiogram (ECG), serum troponin I level, end-tidal sevoflurane, and total dose of morphine in addition transthoracic echocardiography to the postoperative in cases with elevated serum troponin I level. Main Results: The dexmedetomidine decreased heart rate and minimized the changes in blood pressure compared to control group (P < 0.05). Furthermore, it decreased the incidence of myocardial ischemia reflected by troponin I level, ECG changes, and the development of new regional wall motion abnormalities (P < 0.05). Dexmedetomidine decreased the requirement for nitroglycerin and norepinephrine compared to control group (P < 0.05). The incidence of hypotension and bradycardia was significantly higher with dexmedetomidine (P < 0.05). Conclusion: The dexmedetomidine is safe and effective in patients undergoing aortic vascular surgery. It decreases the changes in heart rate and blood pressure during the procedures. It provides cardiac protection in high-risk patients reflected by decreasing the incidence of myocardial ischemia and serum level of troponin. The main side effects of dexmedetomidine were hypotension and bradycardia.http://www.annals.in/article.asp?issn=0971-9784;year=2016;volume=19;issue=4;spage=606;epage=613;aulast=SolimanAortic vascular surgery; Dexmedetomidine; Myocardial ischemia; Myocardial protection; Troponin I |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rabie Soliman Gomaa Zohry |
spellingShingle |
Rabie Soliman Gomaa Zohry The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery Annals of Cardiac Anaesthesia Aortic vascular surgery; Dexmedetomidine; Myocardial ischemia; Myocardial protection; Troponin I |
author_facet |
Rabie Soliman Gomaa Zohry |
author_sort |
Rabie Soliman |
title |
The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery |
title_short |
The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery |
title_full |
The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery |
title_fullStr |
The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery |
title_full_unstemmed |
The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery |
title_sort |
myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Cardiac Anaesthesia |
issn |
0971-9784 |
publishDate |
2016-01-01 |
description |
Objective: The aim of the study was to assess the effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery. Design: A randomized prospective study. Setting: Cairo University, Egypt. Materials and Methods: The study included 150 patients undergoing aortic vascular surgery. Intervention: The patients were classified into two groups (n = 75). Group D: The patients received a loading dose of 1 μg/kg dexmedetomidine over 15 min before induction and maintained as an infusion of 0.3 μg/kg/h to the end of the procedure. Group C: The patients received an equal volume of normal saline. The medication was prepared by the nursing staff and given to anesthetist blindly. Measurements: The monitors included the heart rate, mean arterial blood pressure, central venous pressure, electrocardiogram (ECG), serum troponin I level, end-tidal sevoflurane, and total dose of morphine in addition transthoracic echocardiography to the postoperative in cases with elevated serum troponin I level. Main Results: The dexmedetomidine decreased heart rate and minimized the changes in blood pressure compared to control group (P < 0.05). Furthermore, it decreased the incidence of myocardial ischemia reflected by troponin I level, ECG changes, and the development of new regional wall motion abnormalities (P < 0.05). Dexmedetomidine decreased the requirement for nitroglycerin and norepinephrine compared to control group (P < 0.05). The incidence of hypotension and bradycardia was significantly higher with dexmedetomidine (P < 0.05). Conclusion: The dexmedetomidine is safe and effective in patients undergoing aortic vascular surgery. It decreases the changes in heart rate and blood pressure during the procedures. It provides cardiac protection in high-risk patients reflected by decreasing the incidence of myocardial ischemia and serum level of troponin. The main side effects of dexmedetomidine were hypotension and bradycardia. |
topic |
Aortic vascular surgery; Dexmedetomidine; Myocardial ischemia; Myocardial protection; Troponin I |
url |
http://www.annals.in/article.asp?issn=0971-9784;year=2016;volume=19;issue=4;spage=606;epage=613;aulast=Soliman |
work_keys_str_mv |
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