Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury

Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury

Abstract Background Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies have shown protective effects of conditioned medium (CM) from bone marrow-...

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Bibliographic Details
Main Authors: Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck, Gábor Szabó
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Stem Cell Research & Therapy
Subjects:
Ischemia/reperfusion
Endothelial function
Mesenchymal stem cells
Conditioned medium
Brain death
Online Access:https://doi.org/10.1186/s13287-021-02166-3

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